Detail of "5262-39-5"

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CAS Number:
5262-39-5
Name:
Glycine,N-(carboxycarbonyl)-
Molecular Structure:
Formula:
C₄H₅NO₅
Molecular Weight:
147.09
Synonyms:
N-Oxaloglycine;Oxamicacid, (carboxymethyl)- (7CI,8CI);N-Oxalylglycine;Oxalylglycine;
Density:
1.638 g/cm³
Hazard Symbols:
Xi

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Use of isocitrate dehydrogenase inhibitors for diagnosis and treatment of cancer: Use of isocitrate dehydrogenase inhibitors for diagnosis and treatment of cancer. Einat, Paz; Deiss, Louis; Maya, Ruth (Israel ). U.S. Pat. Appl. Publ. US 2004067234 A1 8 Apr 2004,39 pp., which (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K039-395. NCL: 424155100; 310036000; 514012000. APPLICATION: US 2003-618143 11 Jul 2003. PRIORITY: US 2002-PV395364 11 Jul 2002; US 2002-PV428805 25 Nov 2002. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 3, 7, 14 The present invention discloses uses for the IDH gene and/or polypeptide and/or modulators thereof in the diagnosis and treatment of apoptosis-related diseases. In particular, it relates to antisense oligonucleotides, antibodies and chem.In this experiment, several chemicals are used like 5262-39-5 inhibitors of isocitrate dehydrogenase or its mRNA for treatment of cancer. .

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1a prolyl hydroxylase inhibitors: All Rights Reserved. Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1a prolyl hydroxylase inhibitors. Warshakoon, Namal C.; Wu, Shengde; Boyer, Angelique; Kawamoto, Richard; Sheville, Justin; Renock, Sean; Xu, Kevin; Pokross, Matthew; Zhou, Songtao; Winter, Carol; Walter, Richard; Mekel, Marlene; Evdokimov, Artem G. (Drug Discovery Division, Procter and Gamble Pharmaceuticals Inc., Mason, OH 45040, USA). Bioorganic & Medicinal Chemistry Letters, 16(21), 5517-5522 (English) 2006 Elsevier Ltd. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) Section cross-reference(s): 27 A new series of potent 8-hydroxyquinolines was designed based on the newly resolved x-ray crystal structure of EGLN-1. Both alkyl and aryl 8-hydroxyquinoline-7-carboxyamides were good HIF-1a prolyl hydroxylase (EGLN) inhibitors. In subsequent VEGF induction assays, these exhibited potent VEGF activity. In addn. 5262-39-5 are also occured in this study., this class of compds. did show the ability to stabilize HIF-1a. .