Detail of "52628-64-5"

Reference

Microbial manufacture of prednisolone-17-acetate from 11-desoxy-1,4-dien-3-oxo steroids

Microbial manufacture of prednisolone-17-acetate from 11-desoxy-1,4-dien-3-oxo steroids. Truckenbrodt, Georg; Porwol, Karin; Steppan, Horst; Hess, Lilian; Roeder, Bernd; Stopsack, Heinz; Auweiler, Joerg; Langbein, Gerhard; Henkel, Harry (VEB Jenapharm, Germany). Ger.In this experiment, several chemicals are used like 52628-64-5 (East) DD 290217 A5 23 May 1991, 5 pp. (German Democratic Republic). CODEN: GEXXA8. CLASS: ICM: C12P033-08. ICS: A61K031-57. APPLICATION: DD 85-281608 10 Oct 1985. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) Prednisolone-17-acetate is prepd. with fungi, esp. 75425-50-2 and 49751-53-3 which are cas registry numbers of chemicals are mentioned. Cochliobolus lunatus, Absidia orchidis, and A. coerula, from 11-desoxy-1,4-dien-3-oxo steroids which are esterified at the 17 position and which may be esterified in other positions. The pH must be maintained at 5-7 to prevent hydrolysis of the esters. Using these fungi, yields of prednisolone acetate varied from 63-69% using 17,21-(1'-ethoxyethylidendioxy)-pregna-1,4-dien-3,20-dione or 17-acetoxy-21-hydroxypregna-1,4-dien-3,20-dione as substrate. ..