CAS No.52645-53-1,Permethrin Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	52645-53-1
Name:	Permethrin
Article Data:	34

Formula:	C₂₁H₂₀Cl₂O₃
Molecular Weight:	391.294
Synonyms:	Corsair;InsomniaInsorbcid MP;Ecsumin;Dragnet;Ectiban;Cyclopropanecarboxylic acid,3-(2,2-dichloroethenyl)-2,2-dimethyl-,(3-phenoxyphenyl)methyl ester;Riapan A;NIA 33297;S 3151;FMC 41655;Exmin;SBP 15131TEC;Damminix;Perigen;Perigen W;KaleCollards are also indexed at this headingKaleait;Pounce;Stomoxys calcitransStablefly is also indexed at this headingStomozan;MP 79;KestrelThis heading is used only when the specific taxonomycannot be established from the original documentKestrel (pesticide);NRDC 143;Chinetrin;Pertrin E;Imperator;Kavil;Bematin 987;JF 7065;ICI-PP 557;Anomethrin N;WL 43479;Kudos;Permasect;FMC 33297;m-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate;Permethrin;
EINECS:	258-067-9
Density:	1.293 g/cm³
Melting Point:	34-35 °C
Boiling Point:	465.9 °C at 760 mmHg
Flash Point:	159.4 °C
Solubility:	insoluble in water
Appearance:	Crystalline Solid
Hazard Symbols:	Xn, N, T, F
Risk Codes:	20/22-43-50/53-39/23/24/25-23/24/25-11-51/53-36-20/21/22
Safety:	13-24-36/37/39-60-61-45-36/37-16-7-26
Transport Information:	UN1230 3/PG 2
PSA:	35.53000
LogP:	6.11330

Synthetic route

: 2,2-Dimethyl-3-(2,2,2-trichloro-ethyl)-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester

: 52645-53-1
permethrin

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene Heating;	100%

: 2304-30-5
tetra-n-butylphosphonium chloride

: 13826-35-2
3-Phenoxybenzyl alcohol

: 63142-59-6
4-(2,2-dichloroethenyl)dihydro-5,5-dimethyl-2(3H)-furanone

: 52645-53-1
permethrin

Conditions

Conditions	Yield
With potassium hydroxide; thionyl chloride In ice-water; toluene; benzene	95%

...Expand

: 61898-95-1
cis,trans methyl 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylate

: 13826-35-2
3-Phenoxybenzyl alcohol

A: (3-phenoxyphenyl)methyl 2,2-dimethyl-3-(2-chloroethynyl)cyclopropanecarboxylate

B: 52645-53-1
permethrin

Conditions

Conditions	Yield
With lithium methanolate In methanol; xylene at 100 - 145℃; for 12h; Heating / reflux;	A 0.1% B 94%
With sodium methylate In methanol	A 1.1% B 81%

...Expand

: 52314-67-7
permethric acid chloride

: 13826-35-2
3-Phenoxybenzyl alcohol

: 52645-53-1
permethrin

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; N,N,N,N,-tetramethylethylenediamine; potassium carbonate In potassium hydroxide at 20 - 25℃; for 1.5h; pH=11.5; Schotten-Baumann-type reaction;	93%
With 1-methyl-1H-imidazole; N,N,N,N,-tetramethylethylenediamine; potassium carbonate In acetonitrile at 0 - 25℃; for 2h;	92%

: 60066-52-6
3-phenoxybenzyl 4,6,6,6-tetrachloro-3,3-dimethylhexanoate

: 52645-53-1
permethrin

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran	75%

: 13826-35-2
3-Phenoxybenzyl alcohol

: 52645-53-1
permethrin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH2Cl2 / 0.83 h / -78 - 20 °C 2: 100 percent / DBU / benzene / Heating View Scheme
pyridine In benzene

: [2,2-Dimethyl-3-(2,2,2-trichloro-ethyl)-cyclopropyl]-hydroxy-acetonitrile

: 52645-53-1
permethrin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, -78 deg C, 15 min 2: CH2Cl2 / 0.83 h / -78 - 20 °C 3: 100 percent / DBU / benzene / Heating View Scheme

: [2,2-Dimethyl-3-(2,2,2-trichloro-ethyl)-cyclopropyl]-oxo-acetonitrile

: 52645-53-1
permethrin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH2Cl2 / 0.83 h / -78 - 20 °C 2: 100 percent / DBU / benzene / Heating View Scheme

: 546-68-9
titanium(IV) isopropylate

: 61898-95-1
cis,trans methyl 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylate

: 13826-35-2
3-Phenoxybenzyl alcohol

: 52645-53-1
permethrin

Conditions

Conditions	Yield
With nitrogen

...Expand

: 61898-95-1
cis,trans methyl 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylate

: 13826-35-2
3-Phenoxybenzyl alcohol

: 52645-53-1
permethrin

Raw Materials

100-44-7

Downstream Products

Total:167 Page 1 of 5 1 2 3 4 5 Next>>

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Chemistry

IUPAC Name: (3-phenoxyphenyl)methyl(1R,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
Molecular Formula: C₂₁H₂₀Cl₂O₃
Molecular Weight: 391.29 g/mol
EINECS: 258-067-9
Classification Code: Agricultural Chemical; Ectoparasiticide; Enzyme Inhibitors; Human Data; Insecticide; Insecticides; Mutation data; Pesticides; Reproductive Effect; Skin / Eye Irritant; Tumor data
Index of Refraction: 1.615
Molar Refractivity: 105.69 cm³
Molar Volume: 302.5 cm³
Surface Tension: 50.5 dyne/cm
Density: 1.293 g/cm³
Flash Point: 159.4 °C
Enthalpy of Vaporization: 72.76 kJ/mol
Boiling Point: 465.9 °C at 760 mmHg
Melting Point: 34-35 °C
storage temperature: 0-6 °C
Water Solubility: insoluble
Stability: Stable. Incompatible with strong oxidising agents.
Vapour Pressure of Permethrin (CAS NO.52645-53-1): 7.41E-09 mmHg at 25 °C

Uses

Permethrin (CAS NO.52645-53-1) is used as synthetic pyrethroid insectide, more stable to light and at least as active as the natural pyrethrins and with low mammalian toxicity.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - domestic	LD50	oral	32gm/kg (32000mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
chicken	LD50	oral	7gm/kg (7000mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: IRRITABILITY GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	JAT, Journal of Applied Toxicology. Vol. 7, Pg. 367, 1987.
duck	LD50	oral	11300mg/kg (11300mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
guinea pig	LD50	oral	4gm/kg (4000mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A316, Pg. 1984,
man	LD50	unreported	> 4gm/kg (4000mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
man	TDLo	oral	2270mg/kg (2270mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 57, 1998.
mouse	LC50	inhalation	685mg/m3 (685mg/m3)		Yakkyoku. Pharmacy. Vol. 30, Pg. 1635, 1979.
mouse	LD50	intraperitoneal	429mg/kg (429mg/kg)		Ecotoxicology and Environmental Safety. Vol. 18, Pg. 27, 1989.
mouse	LD50	intravenous	31mg/kg (31mg/kg)		Toxicology and Applied Pharmacology. Vol. 66, Pg. 153, 1982.
mouse	LD50	oral	424mg/kg (424mg/kg)		Ecotoxicology and Environmental Safety. Vol. 18, Pg. 27, 1989.
mouse	LD50	skin	> 10gm/kg (10000mg/kg)		Yakkyoku. Pharmacy. Vol. 30, Pg. 1635, 1979.
mouse	LD50	subcutaneous	10gm/kg (10000mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Bochu Kagaku. Scientific Pest Control. Vol. 41, Pg. 143, 1976.
mouse	LD50	unreported	680mg/kg (680mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA BEHAVIORAL: ATAXIA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(9), Pg. 69, 1988.
mouse	LDLo	intracrebral	600ug/kg (0.6mg/kg)		Toxicology and Applied Pharmacology. Vol. 66, Pg. 290, 1982.
quail	LD50	oral	13500mg/kg (13500mg/kg)		Defense des Vegetaux. Vol. 32, Pg. 168, 1978.
rabbit	LD50	oral	4gm/kg (4000mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A316, Pg. 1984,
rabbit	LD50	skin	> 2gm/kg (2000mg/kg)		Farm Chemicals Handbook. Vol. -, Pg. C233, 1991.
rat	LC50	inhalation	485mg/m3 (485mg/m3)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 55(12), Pg. 21, 1990.
rat	LD	intravenous	> 270mg/kg (270mg/kg)		Nature. Vol. 246, Pg. 169, 1973.
rat	LD50	oral	383mg/kg (383mg/kg)		National Technical Information Service. Vol. AD-A047-284,
rat	LD50	skin	1750mg/kg (1750mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(9), Pg. 69, 1988.
rat	LD50	subcutaneous	6600mg/kg (6600mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA	Bochu Kagaku. Scientific Pest Control. Vol. 41, Pg. 143, 1976.
rat	LD50	unreported	537mg/kg (537mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: COMA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(9), Pg. 69, 1988.

Safety Profile

Poison by inhalation, intravenous, and intracerebral routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. A skin irritant. When heated to decomposition it emits toxic fumes of Cl⁻. See also ESTERS.
Hazard Codes: Harmful Xn, Dangerous N, Toxic T, Flammable F
Risk Statements: 20/22-43-50/53-39/23/24/25-23/24/25-11-51/53-36-20/21/22
R20/22:Harmful by inhalation and if swallowed.
R43:May cause sensitization by skin contact.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R39:Danger of very serious irreversible effects.
R11:Highly flammable.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R36:Irritating to eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 13-24-36/37/39-60-61-45-36/37-16-7-26
S13:Keep away from food, drink and animal foodstuffs.
S24:Avoid contact with skin.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN1230 3/PG 2
RTECS: GZ1255000

Specification

Permethrin (CAS NO.52645-53-1), its Synonyms are Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester ; Cyclopropanecarboxylic acid, 3-(2,2-dichlorovinyl)-2,2-dimethyl-, 3-phenoxybenzyl ester, (+-)-, (cis,trans)- ; Permethrin ; m-Phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate ; Permethrinfog ; Anomethrin N . It is crystalline solid.