Detail of "52665-74-4"

Reference

Ceramide dependent-stabilization of BACE1 in relation to treatment of Alzheimer's disease

Some chemicals with cas registry numbers like 124753-97-5 and 52665-74-4 are also used. Ceramide dependent-stabilization of BACE1 in relation to treatment of Alzheimer's disease. Puglielli, Luigi; Kovacs, Dora M. (The General Hospital Corporation, USA). PCT Int. Appl. WO 2005009374 A2 3 Feb 2005, 64 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K. APPLICATION: WO 2004-US23476 21 Jul 2004. PRIORITY: US 2003-PV489955 21 Jul 2003. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) The invention relates to methods and products for inhibiting ceramide assocd. Ab (amyloid b-peptide) accumulation, which is assocd. with control of BACE1 steady-state levels. The invention is useful for screening compds. for such activity, as well as diagnosing, preventing, and treating Alzheimer's disease and other disorders assocd. with b-secretase processing of substrates. .

Streptomyces bannaensis, manumycin prepared by fermentation of this strain and its application

Streptomyces bannaensis, manumycin prepared by fermentation of this strain and its application. Lu, Weichuan; Zhang, Hua; Dong, Yuesheng; Jiang, Chenglin; Zheng, Zhihui; Jiang, Yi; Li, Wenjun; Lu, Xinhua; Li, Shaojing; Ren, Xiao (North China Pharmaceutical Group Co., Ltd.; Yunnan Institute of Microbiology, Peop. Rep. China). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1473927 A 11 Feb 2004, 13 pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. CLASS: ICM: C12N001-20. ICS: C12P017-02. APPLICATION: CN 2002-125411 6 Aug 2002. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) Section cross-reference(s): 1 The invention relates to the application of Streptomyces bannaensis N98-1,272 to prep. manumycin, which has three structures and whose active site is at epoxyethane ring, by fermn.There are some commonly used reagents with their cas registry numbers 52665-74-4 and 139023-59-9 in this article. The invention also relates to the application of manumycins which inhibit acetyl cholinesterase (AchE) to prep. the medical prepns. for treating Alzheimer's disease. .