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| CAS No.: | 52712-76-2 |
|---|---|
| Name: | Bunazosin hydrochloride |
| Molecular Structure: | |
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|
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| Formula: | C19H27 N5 O3 . Cl H |
| Molecular Weight: | 409.97 |
| Synonyms: | 1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride (9CI); Bunazosin hydrochloride; DDQ; DDQ (pharmaceutical);Detantol; E 643 |
| Density: | 1.221g/cm3 |
| Melting Point: | 280-282° |
| Boiling Point: | 620.6°Cat760mmHg |
| Flash Point: | 329.1°C |
| Safety: | Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl. |
| PSA: | 93.81000 |
| LogP: | 3.45410 |
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Chemistry
IUPAC Name: Bunazosin hydrochloride
Synonyms: Bunazosin hydrochloride ; Bunazosin hydrochloride ; Bunzaosin HCL ; Bunazosin HCL ; 1-(4-Amino-6，7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1，4-diazepine hydrochloride ; Detantol ; E-643 ; Detantol-R
Molecular Structure: 
Molecular Formula : C19H27N5O3.HCl
Molecular Weight : 409.91
CAS NO: 52712-76-2
Flash Point: 329.1 °C
Melting point: 280 ~ 282 °C.
Enthalpy of Vaporization: 91.97 kJ/mol
Boiling Point: 620.6 °C at 760 mmHg
Vapour Pressure: 2.52E-15 mmHg at 25°C
Uses
Bunazosin hydrochloride (CAS NO.52712-76-2) is a blocking agent to αl-receptor , almost does not affect heart rate.
Bunazosin hydrochloride (CAS NO.52712-76-2) is mainly for hypertension of primary, renal, pheochromocytoma-induced .
Production
1:4 - Amino--2 - chloro -6,7 - dimethoxy-quinazoline and 1 - A acyl-piperazine, which are refluxed in butanol ; generated compounds (I) in 9% hydrochloric acid reflux, get compound (Ⅱ), yield 80.4%. reaction with N-Butyl chloride in acetone , generating Bunazosin hydrochloride (CAS NO.52712-76-2)
.
Toxicity Data With Reference
| 1. | orl-rat LD50:980 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),843. | ||
| 2. | scu-rat LD50:365 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),843. | ||
| 3. | ivn-rat LD50:50 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),843. | ||
| 4. | ims-rat LD50:152 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),843. | ||
| 5. | orl-mus LD50:1201 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 17 (1983),843. |
Safety Profile
Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.