Detail of "52729-29-0"

Reference

Stabilization of macrolide antibiotics in oral formulations

Stabilization of macrolide antibiotics in oral formulations. (Toyo Jozo Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59104326 A2 16 Jun 1984 Showa, 35 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K047-00. ICA: A61K031-71. APPLICATION: JP 82-212942 4 Dec 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Oral formulations contain 16-member ring antibiotic macrolides stabilized by one or more stabilizers at pH 3~10. The stabilizers are glycine [56-40-6], glycine aluminum salt [52729-29-0], L-alanine [56-41-7], monosodium glutamate [142-47-2], monosodium aspartate [3792-50-5], etc. Thus, granules consisting of 3''-propionylleucomycin A5 [74014-51-0] 105.3, anhyd. silicic acid 30.0, and hydroxypropyl Me cellulose 7 g were mixed with other granules consisting of glycine 170, citric acid 0~40, anhyd. silicic acid 10, and hydroxypropyl Me cellulose 5 g. To this mixt. were added hydroxypropyl cellulose, Avicel PH-301, and Mg stearate. The mixt. was made into tablets (430 mg/tablet).

An in vitro adsorption study of flurazepam on some antacids and excipients

An in vitro adsorption study of flurazepam on some antacids and excipients. El Gamal, S. S.; Boraie, N. A.; Naggar, V. F. (Fac. Pharm., Univ. Alexandria, Egypt). Pharm. Ind., 48(10), 1207-10 (English) 1986. CODEN: PHINAN. ISSN: 0031-711X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The adsorption of flurazepam (I) [17617-23-1] onto some antacids and excipients, from 0.05N HCl soln., was detd. at 37°. Adsorption occurred to varying extents. Mg trisilicate exhibited the highest adsorptive capacity for the drug, followed by Al glycinate [52729-29-0], and Bi carbonate [18400-34-5], while a colloidal SiO2 gave an intermediate power. Microcryst. cellulose [9004-34-6] and Mg stearate [557-04-0] gave lower values. Kaolin and talc had a rather poor capacity of adsorption for the drug. Al(OH)3, MgO and dihydroxyaluminium Na carbonate unexpectedly showed a neg. adsorption effect. The Langmuir relationship was obeyed in case of Mg trisilicate and Bi carbonate. The effect of the amt. adsorbed on the percent desorbed in 0.In this experiment, several chemicals are used like 14807-96-6 and 557-04-0 05N HCl was also investigated. The extent of adsorption was correlated to the nature of the adsorbent surface and the chem. structure of the adsorbate. Careful in vitro and in vivo testing of drug availability is advisable prior to the administration of drug-antacid combination or to the formulation of oral dosage forms of the drug. .