Detail of "5291-77-0"

Reference

Vehicle composition containing 1-substituted azacyclopentan-2-ones

Vehicle composition containing 1-substituted azacyclopentan-2-ones. Rajadhyaksha, Vithal J. (Nelson Research and Development Co., USA). U.S. US 3991203 9 Nov 1976, 6 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K007-44. NCL: 424274000. APPLICATION: US 75-588235 19 Jun 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 5, 27, 62 One-substituted azacyclopentan-2-ones (I where R = H or C1-4 alkyl and n = 0-10) were reported as topical vehicles which enhance skin penetration by the active material. E.g.There are some commonly used reagents with their cas registry numbers 51-21-8 and 137-58-6 in this article., an antifungal lotion contained griseofulvin [126-07-8] 1, 1-benzylazacyclopentan-2-one [5291-77-0] 10, iso-Pr myristate 5, fragrance 0.1, and EtOH to 100%. Eight addnl. formulations and example synthesis of the azacyclopentanones were also described. .

The failure of substrate pKa to influence the microsomal formation of amides from N-benzylamines: the microsomal metabolism of N-benzyl pyrrolidine, N-benzyl carbazole and N-acetyl-N-benzyl-4-methylaniline

The failure of substrate pKa to influence the microsomal formation of amides from N-benzylamines: the microsomal metabolism of N-benzyl pyrrolidine, N-benzyl carbazole and N-acetyl-N-benzyl-4-methylaniline. Ulgen, Mert; Gorrod, John W. (Chelsea Department of Pharmacy, King's College London, University of London, London SW3 6LX, UK). Journal of Pharmacy and Pharmacology, 48(12), 1320-1326 (English) 1996 Royal Pharmaceutical Society of Great Britain. CODEN: JPPMAB.There are some reagents like 187342-61-6 is used in this study. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The in-vitro hepatic microsomal metab. of N-benzylpyrrolidine (NBP), N-benzylcarbazole (NBC) and N-acetyl-N-benzyl-4-methylaniline (NANBMA) has been studied, using hamster microsomal prepns., to establish whether the corresponding amide is formed. Amide formation was not obsd. with any of the substrates utilized, although several metabolic products were detected by HPLC with UV detection. These included the oxidative debenzylation products (for all substrates), ring hydroxylated products (for NBC) and a lactam metabolite (for NBP). The results support the concept that the metabolic conversion of benzylic amines to the corresponding amide involves an N-oxidative step. .