Detail of "53-79-2"

Reference

Morphological changes in CHO and VERO cells treated with T-2 mycotoxin

Morphological changes in CHO and VERO cells treated with T-2 mycotoxin. Correlation with inhibition of protein synthesis. Trusal, L. R. (Army Med. Res. Inst. Infect. Dis., Fort Detrick, MD, USA). Report, AD-A146618/4/GAR, 25 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1986, 85(1), 53 (English) 1984. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) Exposure of CHO and VERO cells to toxin T 2 (I) [21259-20-1] (T-2 mycotoxin) resulted in several morphol. changes which appeared to be directly related to inhibition of protein synthesis, the basic in vitro mechanism of action of the toxin. These changes, which occurred in both cell types, included disassocn. of polysomes and mitochondrial cristae alterations. In addn., CHO cells displayed membrane bleb formations which were either a result of protein synthesis inhibition or a specific early pathol. response. Bleb formations were not obsd. in VERO cells. Similar morphol. changes, were found in both cell types exposed to established inhibitors of protein synthesis; puromycin [53-79-2] or anisomycin [22862-76-6].

The inhibition of translation in ethylene-induced tobacco abscission

The inhibition of translation in ethylene-induced tobacco abscission. Henry, Egbert W.; Payne, Kenneth J.; Yeekpeh, Julia K. (Dep. Biol. Sci., Oakland Univ., Rochester, MI 48063, USA). Proc. Plant Growth Regul. Soc. Am., 9th, 36-49 (English) 1982. CODEN: PPGRDG. ISSN: 0731-1664. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Tobacco flower pedicel abscission was not prevented when actinomycin D [50-76-0] and ethylene [74-85-1] were applied, also, the inhibitor did not prevent an increase in rough endoplasmic reticulum (RER). However, application of cycloheximide [66-81-9] plus ethylene prevented abscission and inhibited the increase of RER. The translocation process was more directly involved in ethylene-induced abscission than transcription, thereby allowing for the assembly of previously transcribed mRNA, rather than in vivo, new transcription. Several inhibitors of protein synthesis, azauracil [461-89-2], fluoroalanine [43163-93-5], puromycin [53-79-2], cycloheximide, and actinomycin D, are compared in terms of their ability to inhibit peroxidase [9003-99-0] synthesis over a 5 h time-course period, with and without ethylene treatment.