Reference

Effect of sodium carboxymethyl cellulose on the electrophoretic mobility of the chloramphenicol palmitate particles

Effect of sodium carboxymethyl cellulose on the electrophoretic mobility of the chloramphenicol palmitate particles. Djuric, Zorica; Jovanovic, Milica (Inst. Pharm. Tehnol., Fac. Pharm., Belgrade, Yugoslavia). Arh. Farm., (3-4), 133-7 (Serbo-Croatian) 1984. CODEN: ARFMAC. ISSN: 0004-1963. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The sp. cond. of a chloramphenicol palmitate [530-43-8] suspension (250 mg/L) was pos. correlated with CM-cellulose (CMC) [9004-32-4] concn. (1-15 g/L) and neg. correlated with pH (4-7) of the suspension. The electrophoretic mobility of the suspended particles was pos. correlated with pH of the suspension; it was a complex function of CMC concn. Storage of the suspension (7 days at 25°) caused only minor changes in its properties. The effects of interaction of drugs with auxilliary substances on stability of the prepns. are discussed.

Suitability of rigid poly(vinyl chloride) bottles for liquid oral products

Suitability of rigid poly(vinyl chloride) bottles for liquid oral products. Shah, R. C.; Raman, P. V.; Shah, B. M. (Mac Lab. Ltd., Bombay, India). Pharm. J., 221(5979), 58-9 (English) 1978. CODEN: PHJOAV. ISSN: 0031-6873. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) A chloramphenicol palmitate [530-43-8] suspension in sugar syrup vehicle packed in amber PVC [9002-86-2] bottles curdled and discolored, while the same prepn. packed in amber glass bottles kept well throughout a 2-yr period. A vitamin B complex and a cough syrup showed no change in color, clarity, taste or smell when packed in PVC and glass bottles. The B complex elixir deteriorated over 2 yr 50% with respect to B and 10-20% with respect to other vitamins, but the losses were similar in both bottles. The ease of dispersion, taste, smell and viscosity of a kaolin-pectin compn. compared very well for both types of bottles. Thus, all but the chloroamphenicol prepn. may be stored in PVC bottles for 2 yr.