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Plasmid involvement in production of and immunity to the staphylococcin-like peptide pep 5

Plasmid involvement in production of and immunity to the staphylococcin-like peptide pep 5. Ersfeld-Dressen, Hildegard; Sahl, Hans Georg; Brandis, Henning (Inst. Med. Mikrobiol. Immunol., Univ. Bonn, Bonn D-5300/1, Fed. Rep. Ger.). J. Gen. Microbiol., 130(11), 3029-35 (English) 1984. CODEN: JGMIAN. ISSN: 0022-1287. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) The staphylococcin [53026-91-8]-like peptide Pep 5 [84931-86-2] is produced by the penicillin [61-33-6] resistant strain Staphylococcus epidermidis 5. This strain is immune to the peptide. Plasmid anal. of S. epidermidis 5 by agarose gel electrophoresis and electron microscopy demonstrated 5 plasmids with mol. wts. that ranged from 5.8 ′ 106 to 29 ′ 106. Variants of S. epidermidis 5 that did not produce Pep 5 or which had become penicillin sensitive were induced by various curing treatments. Strains lacking the 13.9 ′ 106 mol. wt. plasmid (pED503) failed to produce Pep 5. Plasmid pED503 is also responsible for the immunity of the producer cell to Pep 5. Plasmid pED502 could be transformed into S. aureus RN 981 which then became resistant to penicillin. Plasmid pED503 could not be transformed into S. aureus RN 981, but could be transformed into S. epidermidis 5 variants that had been previously cured of this plasmid; the transformants then regained the properties of Pep 5 prodn. and immunity.