Reference

Assay of isobutylpiperazine

Assay of isobutylpiperazine. Ma, Derong; Zhang, Tao (Wuxi First Pharm. Plant, Wuxi, Peop. Rep. China). Yiyao Gongye, (10), 8-10 (Chinese) 1983. CODEN: YIGODN. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Isobutylpiperazine [5308-28-1] was detd. by potentiometric titrn. and neutralization titrn. Isobutylpiperazine (1.2 g) was dissolved in 40 mL distd. H2O and the soln. was subjected to potentiometric titrn. with 0.5N HCl. Based on the potentiometric titrn., Cresol Red was selected as an indicator for the neutralization titrn. Thus, 1.5 g isobutylpiperazine was dissolved in 25 mL distd. H2O, mixed with 1 drop of Cresol Red, and the mixt. was titrated with 0.5N HCl to yellow color for quant. anal. The isobutylpiperazine content detd. by the potentiometric method was 94.51% compared to 94.55% for the neutralization titrn. method. Piperazine slightly interfered with the detn.