Reference

Reducing serum glucose levels

Reducing serum glucose levels. Gadekar, Shreekrishna M. (Affiliated Medical Research, Inc., USA). U.S. US 4042699 16 Aug 1977, 8 pp. Division of U.S. 3,974,281. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-44. NCL: 424263000.Several reagents such as 53427-93-3 is used here. APPLICATION: US 72-315836 18 Dec 1972. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 27 5-Methyl-1-phenyl-2(1H)-pyridone (AMR-69)(I) [53179-13-8] is prepd. and formulated as tablets and injection solns. which decrease blood serum glucose levels in humans and mammals but are non-irritating. For example, 5-methyl-2(1H)-pyridone [1003-68-5] was refluxed with iodobenzene [591-50-4], anhyd. K2CO3 and Zn-pptd. Cu powder to give I. An injection soln. contg. 10 mg I/mL was prepd. from I 100, NaCl 2.5 and buffered distd. H2O to 10 mg. I showed oral and i.p. LD50's of 580 and 9 mg/kg, resp., in fasted mice. I also decreased blood serum uric acid [69-93-2] and glucose levels, and showed analgesic and antiinflammatory activity in rats and antipyretic activity in rabbits. .

Simple determination of Pirfenidone in rat plasma via high-performance liquid chromatography

All Rights Reserved. Simple determination of Pirfenidone in rat plasma via high-performance liquid chromatography. Wang, Yongsheng; Zhao, Xiaoping; Zhong, Jiao; Chen, Yan; Liu, Xiaoquan; Wang, Guangji (Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, Peop. Rep. China). Biomedical Chromatography, 20(12), 1375-1379 (English) 2006 John Wiley & Sons Ltd. CODEN: BICHE2. ISSN: 0269-3879. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A simple, rapid, and reliable high-performance liq. chromatog. method was developed and validated for the detn. of Pirfenidone and its major metabolites in rat plasma. Plasma proteins were pptd. with perchloric acid (10%, vol./vol.) and the supernatant after centrifugation was detd. using high-performance liq. chromatog. The anal. was carried out on a Lichrospher C18 column (250 ′ 4.6 mm i.d., 5 mm). The mobile phase consisted of acetonitrile-water contg. 0.2% acetic acid (, vol./vol.) at a flow rate of 1 mL/min. The eluant was detected at 310 nm. The calibration curves were linear over a concn. range from 0.15 to 76.67 mg/mL. The accuracy (relative error) of the assay ranged from -2.6 to 7.9% and the precision (coeff. of variation) was <4.5%. The established method has been successfully applied to a pharmacokinetic study of Pirfenidone following a single oral dose to rats.Except for chemicals metioned above, 77837-08-2 and 53179-13-8 are also used. .