Reference

Studies on imidocarb dihydrochloride in experimental Babesia ovis infection in splenectomized lambs

Studies on imidocarb dihydrochloride in experimental Babesia ovis infection in splenectomized lambs. Hashemi-Fesharki, R. (Dep. Parasitol., Razi State Serum Vaccine Inst., Teheran, Iran). Br. Vet. J., 133(6), 609-14 (English) 1977. CODEN: BVJOA9. ISSN: 0007-1935. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) S.c. treatment of splenectomized lambs, exptl. infected with B. ovis, with imidocarb-2HCl (I) [5318-76-3] (2 mg/kg, daily for 3 days) resulted in a complete elimination of the parasite; no relapse occurred. A bolus administration of 6 mg I/kg was not an effective treatment, and relapse occurred. S.c. inoculation of blood from treated animals (2 mg/kg, daily for 3 days) into untreated noninfected splenectomized lambs did not cause infection. Symptoms of toxicity occurred at 10 mg I/kg, but not at lower doses. In a comparitive study, quinuronium sulfate [135-14-8] was ineffective at 1 mg/kg in eliminating the parasite, and was toxic at this dose level.

The effect of chemotherapy on Babesia bigemina in the tick vector Boophilus microplus

The effect of chemotherapy on Babesia bigemina in the tick vector Boophilus microplus. De Vos, A. J.; Stewart, N. P.; Dalgliesh, R. J. (Anim. Res. Inst., Queensland Dep. Primary Ind., Wacol 4076, Australia). Int. J. Parasitol., 14(3), 249-52 (English) 1984. CODEN: IJPYBT. ISSN: 0020-7519. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Percentages of feeding ticks in which B. bigemina could be detected (infection rates) were detd. following treatment of bovine hosts with each of 4 babesicides. Infection rates were suppressed by imidocarb dipropionate [55750-06-6], quinuronium sulfate [135-14-8] and amicarbalide isethionate [3671-72-5], reaching min. levels 3-4 days after treatment, but imidocarb dihydrochloride [5318-76-3] had comparatively little effect. Total elimination of the parasite from ticks was not achieved. Treatment of tick infested hosts with imidocarb dipropionate or quinuronium sulfate failed to prevent transmission of B. bigemina by transovarian passage or by transfer of adult male ticks. These findings indicate that the use of babesicides for chemotherapy is unlikely to have a significant effect on the rate of transmission of B. bigemina.