Reference

Biochemical effects of dithiolthiones

Biochemical effects of dithiolthiones. Ansher, S. S.; Dolan, P.; Bueding, E. (Sch. Hyg. Public Health, Johns Hopkins Univ., Baltimore, MA 21205, USA). Food Chem. Toxicol., 24(5), 405-15 (English) 1986. CODEN: FCTOD7.Several reagents with their cas registry numbers 3354-37-8 and 50812-37-8 are used here. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Section cross-reference(s): 1 Administration of dithiolthiones to mice in single intragastric doses (2-4 mmol/kg body wt.) or in the diet (0.5% for 14 days), and to rats in the diet (0.1% for 14 days) increased glutathione [70-18-8] levels and the activities of a no. of enzymes in various tissues including the liver and lung. The enzymes affected were glutathione transferase [50812-37-8], (with chlorodinitrobenzene or dichloronitrobenzene), quinone [9032-20-6] and glutathione reductase [9001-48-3], and glucose-6-phosphate [9001-40-5] and 6-phosphogluconate dehydrogenase [9001-82-5], all of which are involved directly or indirectly in the detoxication of xenobiotics, including carcinogens. The dithiolthiones tested in mice were oltipraz [64224-21-1], ADT [532-11-6], 116L [3445-76-9] and 129L [3354-37-8], and in rats, oltipraz. Intragastric administration of dithiolthiones (oltipraz, ADT or 116L; 2 doses each of 1 g/kg body wt.) did not increase glutathione levels or enzyme activities in murine mammary adenocarcinoma transplants. Increases in glutathione levels and enzyme activities similar to those found with dithiolthiones were obsd. when a semi-synthetic diet contg. 10-40% lyophilized cabbage was fed to mice for 30 days. Dithiolthiones that are present in cabbage may play a role in the protective actions of diets high in vegetables against the toxic actions of xenobiotics. The biochem. effects of dithiolthiones may account for the protective actions of these compds. .

Dithiolthione-induced alterations in hepatic glutathione and related enzymes in male mice

Dithiolthione-induced alterations in hepatic glutathione and related enzymes in male mice. Davies, Marc H.; Blacker, Ann M.; Schnell, R. Craig (Med. Cent., Univ. Nebraska, Omaha, NE 68105, USA). Biochem. Pharmacol., 36(4), 568-70 (English) 1987. CODEN: BCPCA6. ISSN: 0006-2952.There are some commonly used reagents with their cas registry numbers 50812-37-8 and 9023-64-7 in this article. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Oral administration of the dithiolthiones, 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (I) [64224-21-1] and 3-(p-methoxyphenyl)-1,2-dithiol-3-thione [532-11-6] to mice increased the activities and levels of GSH [70-18-8], g-glutamylcysteine synthetase [9023-64-7], oxidized glutathione (GSSG) [27025-41-8], glutathione-S-transferase [50812-37-8], and glutathione reductase [9001-48-3]. Glutathione peroxidase [9013-66-5] activity was decreased. The dithiolthiones may protect against hepatotoxins by interacting with the hepatic GSH system. .