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CAS No.: | 532-12-7 |
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Name: | MYOSMINE |
Article Data: | 44 |
Molecular Structure: | |
Formula: | C9H10 N2 |
Molecular Weight: | 146.192 |
Synonyms: | Pyridine,3-(1-pyrrolin-2-yl)- (6CI,7CI,8CI); 2-(3-Pyridyl)-1-pyrroline; Myosmine |
Density: | 1.12g/cm3 |
Melting Point: | 42-44°C |
Boiling Point: | 82-83°C 0,5mm |
Flash Point: | 101.8°C |
Appearance: | Light Yellow Powder |
Hazard Symbols: | R22:Harmful if swallowed.; |
Risk Codes: | R22; |
Safety: | 119254 |
PSA: | 25.25000 |
LogP: | 1.10010 |
4-oxo-4-(pyridin-3-yl)butanenitrile
Myosmine
Conditions | Yield |
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With ammonia; hydrogen; nickel In ethanol at 0℃; | 85% |
With ammonia; hydrogen; nickel In ethanol for 20h; | 69% |
Myosmine
Conditions | Yield |
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With bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile at 20℃; for 12h; | 83% |
Conditions | Yield |
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Stage #1: methyl 3-pyridinecarboxylate; 1-(but-1-enyl) pyrrolidin-2-one With sodium hydride In N,N-dimethyl-formamide at 90℃; for 2h; Stage #2: With hydrogenchloride In water at 110℃; for 12h; Stage #3: With sodium hydroxide In water at 0℃; pH=14; | 77.2% |
1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one
Myosmine
Conditions | Yield |
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Stage #1: 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one With hydrogenchloride In water for 12h; Reflux; Stage #2: With sodium hydroxide In water at 0℃; pH=> 13; | 70% |
1-(pyridin-3-yl)cyclobutanol
Myosmine
Conditions | Yield |
---|---|
With hydrogen azide; sulfuric acid In dichloromethane at 0℃; | 65% |
With hydrogen azide; sulfuric acid In dichloromethane at 0℃; Mechanism; substrate: 1-(3-pyridyl) cyclopentanol; | 65% |
Conditions | Yield |
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With ammonia; hydrogen; nickel In ethanol for 40h; Product distribution; various concentrations and temperatures; | A 53% B 13% |
Conditions | Yield |
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With tert-butylethylene; RhCl(CO)(PFur3)2; caesium carbonate In 1,4-dioxane at 120℃; for 12h; | A n/a B 39% |
3-(1-methyl-pyrrolidin-2-yl)-pyridine
A
Myosmine
B
N-methylmyosmine
C
nicotirine
D
cotinine
Conditions | Yield |
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With 9,10-Dicyanoanthracene; oxygen In acetonitrile for 22h; Mechanism; Irradiation; also TiO2 as electron acceptor, in absence of O2; | A 0.27% B n/a C 0.11% D 1.05% E n/a |
3-pyridinecarboxylic acid ethyl ester
1-benzoylpyrrolidin-2-one
sodium ethanolate
benzene
Myosmine
Conditions | Yield |
---|---|
at 110 - 115℃; Erhitzen des Reaktionsprodukts mit wss.Salzsaeure auf 130grad.; |
Conditions | Yield |
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With sodium ethanolate; benzene Erhitzen des Reaktionsprodukts mit wss. HCl auf 130grad; |