Detail of "532-40-1"

MSDS Download
CAS Number:
532-40-1
Name:
Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-,chloride (1:1)
Superlist Name:
Monophosphothiamine
Molecular Structure:
Formula:
C₁₂H₁₈N₄O₄PS.Cl
Molecular Weight:
380.79
Synonyms:
Phosphoricacid, thiamine ester (6CI);Thiamine, dihydrogen phosphate (ester) (8CI);Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-,chloride (9CI);Thiamine monophosphate chloride;Neurifosforil;Novaneurina;Phosphothiamine;Superneurina;Thiamin monophosphate;Thiaminephosphoric acid ester chloride;
EINECS:
208-536-9

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Metabolism of glutamic and: Metabolism of glutamic and .gamma.-aminobutyric acids in rat brain following the administration of large doses of thiamine and its derivatives. Koval'chuk, V. G. (Otd. Regul. 299-35-4 and 9024-58-2 are cas registry numbers. These chemicals are also mentioned in this article. Obmena Veshchestv, Grodno, USSR). Tezisy Dokl. - Konf. Beloruss. Biokhim. O-va., 2nd, 135-6. Edited by: Vecher, A. S. "Nauka i Tekhnika": Minsk, USSR. (Russian) 1974. CODEN: 33XOAH. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) In rats, thiothiamine (I) [299-35-4] and thiamine propyl disulfide-GABA [60765-72-2] inhibited the activity of glutamate decarboxylase [9024-58-2] and decreased the concn. of GABA [56-12-2] in brain tissue in 1 hr. At 3 hr after thiamine diphosphate [154-87-0] or thiamine monophosphate [532-40-1] administration the activity of .alpha.-ketoglutarate dehydrogenase [9031-02-1] was increased and that of glutamate dehydrogenase was decreased. The thiamine derivs. did not affect brain levels of alanine, asparagine, glutamic acid, aspartate transferase, or alanine transferase. .

Effect of thiamin and its derivatives on sheep: Effect of thiamin and its derivatives on sheep. Rush, A. F. (Altai. S-kh. Inst., Barnaul, USSR). Veterinariya (Moscow), (7), 88-9 (Russian) 1977. CODEN: VETNAL. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Thiamin [59-43-8] and its derivs. thiamin bromide [7019-71-8], cocarboxylase chloride [154-87-0], phosphothiamin [532-40-1], and benphothiamin [22457-89-2] were tested for their effects when given in saline soln. or suspension i.m. to sheep at 0.5-50 mg/kg body wt. Cocarboxylase and phosphothiamin at 0.5 mg/kg were effective in improving heart and digestive tract function and metab. processes; the other 2 derivs. were effective at 5-10 mg/kg, and thiamin was effective at 25 mg/kg. Cocarboxylase at 20-5 mg/kg became toxic.