Detail of "532-94-5"

Reference

Experimental perfusion of isolated liver to study bile secretion and bromsulfalein excretion

Experimental perfusion of isolated liver to study bile secretion and bromsulfalein excretion. Sasayama, Tetsuro; Mizuta, Minoru (Sch. Med., Yamaguchi Univ., Ube, Japan). Bull. Yamaguchi Med. Sch., 22(4), 675-91 (English) 1975. CODEN: BYMSAN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The mechanism of bile secretion and the metab. of an exogenous pigment, bromsulfalein [71-67-0], by the liver was studied by administering 3 drugs to the rat. 71-67-0 and 54-21-7 are also in the experiment. The liver perfusion expts. revealed that Na dehydrocholate [145-41-5] caused a rapid pigment excretion when the hepatic circulation was <1 mL/g liver/min, whereas Na salicylate (I) [54-21-7] caused an increase in bromsulfalein excretion even at a higher rate of hepatic circulation. I also increased the bile secretion. Na hippurate [532-94-5], on the other hand, had no effect on the bile secretion but increased the pigment excretion. Apparently, the mechanism of bile secretion and that of pigment excretion are different. .

Mutagenicity study on O,S-dibenzoyl thiamin hydrochloride in bacteria

Mutagenicity study on O,S-dibenzoyl thiamin hydrochloride in bacteria. Kikuchi, Yasumoto; Yamamoto, Koichi I.; Yamamoto, Kiyoshi S.; Sakamoto, Yutaka (Cent. Res. Div., Takeda Chem. Ind., Ltd., Osaka, Japan). Vitamins, 51(2), 49-55 (Japanese) 1977. CODEN: BTMNA7. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 1 O,S-dibenzoylthiamin hydrochloride (I) [35660-60-7] was tested by the rec-assay and the reversion assay. In the rec-assay with Bacillus subtilis, I gave neg. results at a dose of 10 mg/disk. When Escherichia coli and Salmonella typhimurium were used in the reversion assay, I was not mutagenic at concns. of 500-5000 .mu.g/plate, regardless of treatment with a mammalian metabolic activation system prepd. from phenobarbital-treated rats. Neg. results were also obtained for sodium benzoate [532-32-1] and sodium hippurate [532-94-5], the major metabolites of I in the same test systems as above. Thus, I was not mutagenic under the present exptl. conditions.