Products Categories
CAS No.: | 533-45-9 |
---|---|
Name: | Clomethiazole |
Article Data: | 19 |
Molecular Structure: | |
Formula: | C6H8ClNS |
Molecular Weight: | 161.655 |
Synonyms: | 4-Methyl-5-(b-chloroethyl)thiazole;5-(2-Chloroethyl)-4-methylthiazole;5-(b-Chloroethyl)-4-methylthiazole;Chlorethiazol;Chlorethiazole;Chlormethiazol;Chlormethiazole;Clomethiazole;Clomethiazolum;Distraneurin;Emineurina;Somnevrin; |
EINECS: | 208-565-7 |
Density: | 1.219 g/cm3 |
Melting Point: | 127-128 °C |
Boiling Point: | 245.774 °C at 760 mmHg |
Flash Point: | 102.441 °C |
PSA: | 41.13000 |
LogP: | 3.03480 |
Conditions | Yield |
---|---|
With thionyl chloride for 3h; Reflux; | 98% |
With thionyl chloride for 2h; Heating; | 96% |
With phosphorus pentachloride In dichloromethane for 3h; Heating; | 95% |
chlormethiazole
Conditions | Yield |
---|---|
With hydrogenchloride; dihydrogen peroxide |
5-(2-ethoxyethyl)-4-methylthiazole
chlormethiazole
Conditions | Yield |
---|---|
With hydrogenchloride |
5-ethoxy-3-chloro-pentan-2-one
chlormethiazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: concentrated aqueous HCl View Scheme |
2-(2-ethoxy-ethyl)-2-chloro-acetoacetic acid ethyl ester
chlormethiazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: glacial acetic acid; H2SO4 3: concentrated aqueous HCl View Scheme |
3-chloro-3-acetylpropanol
chlormethiazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol 2: concentrated aqueous HCl View Scheme |
3, 5-dichloro-2-pentanone
chlormethiazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / anschliessend Behandeln mit H2O 2: H2O2; concentrated aqueous HCl View Scheme |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20 - 80℃; for 8h; | 98% |
chlormethiazole
dimethyl sulfate
5-(β-Chloroethyl)-3,4-dimethylthiazolium methyl sulfate
Conditions | Yield |
---|---|
In acetone at 20℃; for 24h; | 85% |
chlormethiazole
potassium phtalimide
4-methyl-5-(β-phthalimidoethyl)thiazole
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 100 - 105℃; for 2h; | 67% |
In N,N-dimethyl-formamide (heating); |
5-(2-chloroethyl)-4-methylthiazole (533-45-9) is also named as clomethiazole;chlormethiazole;;ChlormethiazoleHCl;5-(2-Chlorethyl)-4-methylthiazole hydrochloride;Chlorethiazole;Clomethiazolum,and so on.
CAS: 533-45-9
Molecular Formula: C6H8ClNS
Molecular Weight: 161.65
Molecular structure:
EINECS: 208-565-7
Index of Refraction: 1.545
Molar Refractivity: 41.95 cm3
Molar Volume: 132.6 cm3
Polarizability: 16.63 10-24cm3
Surface Tension: 41.8 dyne/cm
Density: 1.218 g/cm3
Flash Point: 102.4 °C
Enthalpy of Vaporization: 46.33 kJ/mol
Boiling Point: 245.8 °C at 760 mmHg
Vapour Pressure: 0.0442 mmHg at 25°C
1. | orl-mus LD50:2110 mg/kg | JMCMAR Journal of Medicinal Chemistry. 7 (1964),167. | ||
2. | ipr-mus LD50:190 mg/kg | APSXAS Acta Pharmaceutica Suecdca. 8 (1971),39. | ||
3. | ivn-mus LD50:94 mg/kg | APSXAS Acta Pharmaceutica Suecdca. 7 (1970),423. |
RTECS: XJ3850000