Detail of "5344-90-1"

CAS Number:
5344-90-1
Name:
Benzenemethanol,2-amino-
Superlist Name:
2-Aminobenzylalcohol
Molecular Structure:
Formula:
C₇H₉NO
Molecular Weight:
123.16
Synonyms:
Benzylalcohol, o-amino- (6CI,7CI,8CI);(2-Aminophenyl)methanol;(o-Aminophenyl)methanol;2-(Hydroxymethyl)aniline;2-Aminobenzenemethanol;2-Aminobenzylalcohol;NSC 1173;[2-(Hydroxymethyl)phenyl]amine;o-(Hydroxymethyl)aniline;o-Aminobenzyl alcohol;o-Aminobenzylic alcohol;
EINECS:
226-293-7
Density:
1.166 g/cm³
Melting Point:
81-83 °C(lit.)
Boiling Point:
275 °C at 760 mmHg
Flash Point:
126.3 °C
Appearance:
white to light yellow crystal powder
Hazard Symbols:
Xn, Xi
Risk Codes:
36/37/38-20/21/22
Safety:
26-36-37/39 Details

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Reference

Characterization of the oxidation of amine metabolites of nitrotoluenes by rat hepatic microsomes: Characterization of the oxidation of amine metabolites of nitrotoluenes by rat hepatic microsomes. Nitrogen- and carbon-hydroxylation. Kedderis, Gregory L.; Rickert, Douglas E. (Dep. Biochem. Toxicol. Pathobiol., Chem. Ind. Inst. Toxicol., Research Triangle Park, NC 27709, USA). Mol. Pharmacol., 28(2), 207-14 (English) 1985. CODEN: MOPMA3. ISSN: 0026-895X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The rat hepatic microsomal oxidn. of amine metabolites of mono- and dinitrotoluene isomers were investigated. Microsomes catalyzed the NADPH-dependent oxidn. of 2-amino-6-nitrobenzyl alc. (I) [98451-51-5], 2-amino-4-nitrobenzyl alc. [78468-34-5], and the isomeric aminobenzyl alcs. to EtOAc-extractable compds. capable of reducing Fe. The microsomal metab. of 2-amino-6-nitrobenzyl alc., a metabolite of the hepatocarcinogen 2,6-dinitrotoluene, was characterized in detail. HPLC anal. indicated the formation of 2 metabolites, both of which were reducing agents. One metabolite was identified as 2-hydroxyamino-6-nitrobenzyl alc. [98451-49-1] by comparison of its chromatog. properties and mass spectrum with those of the authentic compd. Mass spectral, proton NMR, and UV-visible spectroscopic studies suggested that the other metabolite was 2-amino-5-hydroxy-6-nitrobenzyl alc. [98451-50-4]. The microsomal oxidn. of 2-aminobenzyl alc. [5344-90-1] also resulted in the formation of 2 reducing agents, 1 of which was the corresponding hydroxylamine. The formation of 2-hydroxylamino-6-nitrobenzyl alc. from the microsomal oxidn. of 2-amino-6-nitrobenzyl alc. was decreased by known inhibitors of cytochrome P 450 [9035-51-2], whereas heat inactivation of microsomal flavin-contg. monooxygenase had no effect. The rate of formation of both metabolites was increased 1.5-fold by phenobarbital pretreatment. Pretreatment with b-naphthoflavone had no effect on the rate of N-hydroxylation, whereas a small but statistically significant increase in the rate of C-hydroxylation (117% of control) was obsd. The rate of oxidn. of 2-amino-6-nitrobenzyl alc. was lower with microsomes from female rats than with those from males, yielding male/female ratios of 1.34 for aminophenol formation and 3.26 for hydroxylamine formation. Thus, 2-amino-6-nitrobenzyl alc., a metabolite of the hepatocarcinogen 2,6-dinitrotoluene, can be N-hydroxylated by hepatic microsomal cytochrome P 450. The results are consistent with the hypothesis that a hydroxylamine metabolite of 2,6-dinitrotoluene is sulfated in vivo to produce an electrophilic species.

Catalytic epoxidation with molecular oxygen using nickel complex: Catalytic epoxidation with molecular oxygen using nickel complex. Irie, Ryo; Ito, Yoshio; Katsuki, Tsutomu (Fac. Sci. 2461-34-9 and 5344-90-1 are also occured in this study., Kyushu Univ., Fukuoka 812, Japan). Tetrahedron Lett., 32(47), 6891-4 (English) 1991. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The Ni complex, [N,N'-bis[o-(p-toluenesulfonylamino)benzylidene]ethylenediaminato]nick el(II) is a good catalyst for the epoxidn. of olefins with mol. oxygen in the presence of 2-methylpropanal (Mukaiyama's conditions). trans-Stilbene afforded the corresponding trans epoxide in 79% yield under the above conditions. Dihydronaphthelene afforded only a trace of the epoxide. .

Detail of "5344-90-1"

Benzenemethanol,2-amino-

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CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

CAS No.5344-90-1 2-Aminobenzylalcohol

Reference