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| CAS No.: | 535-89-7 |
|---|---|
| Name: | CRIMIDINE |
| Article Data: | 12 |
| Molecular Structure: | |
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| Formula: | C7H10 Cl N3 |
| Molecular Weight: | 171.63 |
| Synonyms: | Pyrimidine,2-chloro-4-(dimethylamino)-6-methyl- (6CI,7CI,8CI);(2-Chloro-6-methylpyrimidin-4-yl)dimethylamine; 2-Chloro-4-(dimethylamino)-6-methylpyrimidine;2-Chloro-4-methyl-6-(dimethylamino)pyrimidine; Castrix; Crimidine; Crimitox;NSC 2017; W 491 |
| EINECS: | 208-622-6 |
| Density: | 1.207g/cm3 |
| Melting Point: | 87oC |
| Boiling Point: | 291.2°Cat760mmHg |
| Flash Point: | 129.9°C |
| Hazard Symbols: |
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| Risk Codes: | R28 |
| Safety: | Deadly poison by ingestion and intraperitoneal routes. Can cause central nervous system damage and convulsions. Intensely poisonous to mammals. A pesticide. When heated to decomposition it emits very toxic fumes of Cl− and NOx. |
| Transport Information: | UN 2811 |
| PSA: | 29.02000 |
| LogP: | 1.50440 |
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Chemistry
Chemistry informtion about Crimidine (CAS NO.535-89-7) is:
IUPAC Name: 2-Chloro-N,N,6-Trimethylpyrimidin-4-Amine
Synonyms: Crimidine Granules(Content<2%) ; Crimidine ; 2-Chloro-N,N,6-Trimethylpyrimidin-4-Amine ; 2-Chloro-4-Dimethylamino-6-Methylpyrimidine ; 2-Chloor-4-Dimethylamino-6-Methyl-Pyrimidine ; 2-Chlor-4-Dimethylamino-6-Methylpyrimidin ; 2-Chloro-4-(Dimethylamino)-6-Methyl-Pyrimidin ; 2-Chloro-4-Methyl-6-Dimethylaminopyrimidine
Product Categories: pharmacetical
MF: C7H10ClN3
MW: 171.63
EINECS: 208-622-6
Density: 1.207 g/cm3
Flash Point: 129.9 °C
Boiling Point: 291.2 °C at 760 mmHg
Vapour Pressure: 0.00198 mmHg at 25°C
Enthalpy of Vaporization: 53.06 kJ/mol
Refractive Index:
Storage temp.: 0-6°C
Merck: 13,2615
Following is the molecular structure of Crimidine (CAS NO.535-89-7) is:
Uses
Crimidine (CAS NO.535-89-7) can be used as a rodenticide.
Production
Raw materials are Sodium hydroxide-->Urea-->Ethyl acetoacetate-->Dimethylamine-->2,4-Dihydroxy-6-methylpyrimidine-->Crotonic acid-->2,4-Dichloro-6-methylpyrimidine .
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LD50 | oral | 22500ug/kg (22.5mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
| dog | LD50 | intraperitoneal | 500ug/kg (0.5mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948. |
| guinea pig | LD50 | intraperitoneal | 2660ug/kg (2.66mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948. |
| guinea pig | LD50 | oral | 2660ug/kg (2.66mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 202, 1966. | |
| mouse | LD50 | intraperitoneal | 420ug/kg (0.42mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948. |
| mouse | LD50 | oral | 1200ug/kg (1.2mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 405, 1989. | |
| rabbit | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948. |
| rabbit | LD50 | oral | 5mg/kg (5mg/kg) | "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 59, 1976. | |
| rabbit | LD50 | unreported | 5mg/kg (5mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 422, 1971. | |
| rat | LD50 | intraperitoneal | 1mg/kg (1mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 307, 1948. |
| rat | LD50 | oral | 1250ug/kg (1.25mg/kg) | Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 139, 1973. | |
| rat | LD50 | skin | > 1gm/kg (1000mg/kg) | "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A099, Pg. 1983, | |
| rat | LD50 | unreported | 1250ug/kg (1.25mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 422, 1971. |
Consensus Reports
EPA Extremely Hazardous Substances List.
Safety Profile
Deadly poison by ingestion and intraperitoneal routes. Can cause central nervous system damage and convulsions. Intensely poisonous to mammals. A pesticide. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Hazard Codes:
T+
Risk Statements:
R28:Very toxic if swallowed.
Safety Statements:
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2588
RTECS: UV8050000
HazardClass: 6.1(a)
PackingGroup: I
Specification
Crimidine (CAS NO.535-89-7) is a brown waxy solid or colorless crystals. It not registered as a pesticide in the U.S. Crimidine neutralizes acids in exothermic reactions to form salts plus water. It may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or less than 7 drops for a 70 kg (150 lb.) person. May cause serious central nervous system damage leading to convulsions.CrimidineE emits highly toxic chloride fumes when heated to decomposition. Avoid acids and acid fumes. Very stable in neutral medium. Avoid decomposing heat.