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| CAS No.: | 5351-23-5 |
|---|---|
| Name: | 4-Hydroxybenzhydrazide |
| Article Data: | 126 |
| Molecular Structure: | |
|
|
|
| Formula: | C7H8N2O2 |
| Molecular Weight: | 152.153 |
| Synonyms: | Benzoicacid, p-hydroxy-, hydrazide (6CI,7CI,8CI);(4-Hydroxybenzoyl)hydrazine;(p-Hydroxybenzoyl)hydrazine;4-Hydroxybenzhydrazide;4-Hydroxybenzohydrazide;4-Hydroxybenzoic acid hydrazide;4-Hydroxybenzoyl hydrazide;INHd 25;NSC 647;p-Hydroxybenzhydrazide;p-Hydroxybenzohydrazide;p-Hydroxybenzoic acidhydrazide;p-Hydroxybenzoic hydrazide;p-Hydroxybenzoyl hydrazide;4-hydroxybenzohydrazide;Benzoic acid, 4-hydroxy-, hydrazide; |
| EINECS: | 226-326-5 |
| Density: | 1.318 g/cm3 |
| Melting Point: | 264-266 °C (dec.)(lit.) |
| Boiling Point: | 274.61°C (rough estimate) |
| Appearance: | White solid. |
| Hazard Symbols: |
 Xi;  C
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-37/39 |
| PSA: | 75.35000 |
| LogP: | 1.08690 |
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| Conditions | Yield |
|---|---|
| With hydrazine hydrate for 18h; Reflux; | 99% |
| With hydrazine hydrate In methanol for 0.05h; Microwave irradiation; | 94.6% |
| With hydrazine hydrate In ethanol for 0.2h; Reflux; Microwave irradiation; | 93% |
- 62500-75-8
C21H18Cl2N4O4
A
- 5351-23-5
4-hydroxybenzoic acid hydrazide
B
- 6476-81-9
2-Dimethylamino-4,6-dihydrazino-sym-triazine
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In 1,4-dioxane for 2h; Heating; | A 98% B 55% |
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In ethanol; water Inert atmosphere; Reflux; | 96% |
| With hydrazine hydrate In ethanol Inert atmosphere; Reflux; | 96% |
| With hydrazine hydrate In ethanol Inert atmosphere; Reflux; | 96% |
| Conditions | Yield |
|---|---|
| Stage #1: 4-hydroxy-benzoic acid With sulfuric acid In ethanol for 6h; Reflux; Stage #2: With hydrazine hydrate; sodium hydrogencarbonate; acetic acid Reflux; | 89% |
| With hydrazine at 250℃; Microwave irradiation; | 83% |
| With hydrazine hydrochloride |
- 61370-95-4
2,4-bis(4-chlorocarbonylphenoxy)-6-methoxy-s-triazine
A
- 19992-28-0
2,4‐dihydrazinyl‐6‐methoxy‐1,3,5‐triazine
B
- 5351-23-5
4-hydroxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In 1,4-dioxane for 2h; Heating; |
- 62500-77-0
C29H18Cl2N4O4
A
- 35968-21-9
2-Diphenylamino-4,6-dihydrazino-sym-triazine
B
- 5351-23-5
4-hydroxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In 1,4-dioxane for 2h; Heating; |
- 66996-57-4
4-Hydroxy-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride
A
- 23541-50-6
daunomycin hydrochloride
B
- 5351-23-5
4-hydroxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
| With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: H2SO4 / Heating 2: hydrazine / H2O / Heating View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 80 percent / H2SO4 2: 70 percent / 35percent aq. hydrazine / Ambient temperature View Scheme |
- 521290-74-4
tert-butyl 2-(4-hydroxybenzoyl)hydrazinecarboxylate
- 5351-23-5
4-hydroxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
| deprotection; |
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Specification
The Benzoic acid,4-hydroxy-, hydrazide, with the CAS registry number 5351-23-5 and EINECS registry number 226-326-5, has the systematic name and IUPAC name of 4-hydroxybenzohydrazide. It is a kind of white to slightly beige fine crystalline powder, and belongs to the following product categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes; Benzoic acid; Phenols. And the molecular formula of the chemical is C7H8N2O2.
The characteristics of Benzoic acid,4-hydroxy-, hydrazide are as followings: (1)ACD/LogP: -0.33; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.33; (4)ACD/LogD (pH 7.4): -0.39; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 15.65; (8)ACD/KOC (pH 7.4): 13.65; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 32.78 Å2; (13)Index of Refraction: 1.622; (14)Molar Refractivity: 40.65 cm3; (15)Molar Volume: 115.3 cm3; (16)Polarizability: 16.11×10-24cm3; (17)Surface Tension: 62.7 dyne/cm; (18)Density: 1.318 g/cm3.
Uses of Benzoic acid,4-hydroxy-, hydrazide: It can react with 2-amino-pyridine-3-carbaldehyde to produce 4-hydroxy-benzoic acid (2-amino-pyridin-3-ylmethylene)-hydrazide. This reaction will need reagent glacial acetic acid, and the menstruum ethanol. The reaction time is 3 hours with heating, and the yield is about 67%.
You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O=C(c1ccc(O)cc1)NN
(2)InChI: InChI=1/C7H8N2O2/c8-9-7(11)5-1-3-6(10)4-2-5/h1-4,10H,8H2,(H,9,11)
(3)InChIKey: ZMZGIVVRBMFZSG-UHFFFAOYAN