Detail of "53632-49-8"

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CAS Number:
53632-49-8
Name:
L-Threonine,N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
Molecular Structure:
Formula:
C44H69 N13 O11
Molecular Weight:
956.1
Synonyms:
AngiotensinII, 1-(N-methylglycine)-5-L-isoleucine-8-L-threonine-; 159: PN: WO02064734SEQID: 159 claimed protein; Sarthran; [Sar1,Ile5,Thr8]-angiotensin II

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Synthesis of [1-sarcosine,8-O-methylserine]angiotensin II and 1-substituted analogs of [8-threonine]angiotensin II as antagonists of angiotensin II: Synthesis of [1-sarcosine,8-O-methylserine]angiotensin II and 1-substituted analogs of [8-threonine]angiotensin II as antagonists of angiotensin II. Khosla, M. C.; Hall, M. M.; Munoz-Ramirez, H.; Khairallah, P. A.; Bumpus, F M.; Seely, J. H.; Thomas, A. M. (Res. Div., Cleveland Clin. Found., Cleveland, Ohio, USA). J. Med. Chem. 61037-89-6 and 11128-99-7 are also in the experiment., 20(2), 253-6 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 34 [1-N-methylisoleucine, 8-threonine]- [60904-03-2], [1-dimethylglycine, 8-threonine]- [60904-04-3], [1-guanidineacetic acid, 8-threonine]- [61037-89-6], des-1-aspartic acid-[8-threonine]- [58108-03-5], and [1-sarcosine, 8-O-methylserine]angiotensin II [61037-88-5], prepd. by solid-phase methods, were less potent inhibitors than [1-sarcosine, 8-threonine]angiotensin II [53632-49-8] of the contractile activity of angiotensin II [11128-99-7] on rabbit aortic strips. Pressor activities and comparative dose ratios detd. in vagotomized ganglion-blocked rats showed the same redn. in potency compared to the 1-sarcosine, 8-threonine analog. Structure-activity relations are discussed. .