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Stimulation of chemiluminescence and resistance against aerogenic influenza virus infection by synthetic muramyl dipeptide combined with trehalose dimycolate

Stimulation of chemiluminescence and resistance against aerogenic influenza virus infection by synthetic muramyl dipeptide combined with trehalose dimycolate. Masihi, K. Noel; Brehmer, Werner; Azuma, Ichiro; Lange, Werner; Mueller, Sybille (Robert Koch Inst., Fed. Health Off., Berlin D-1000/65, Fed. Rep. Ger.). Infect. Immun., 43(1), 233-7 (English) 1984. CODEN: INFIBR. ISSN: 0019-9567. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect on respiratory burst of splenic cells from mice pretreated with oil-in-water emulsions of muramyl dipeptide (MDP) [53678-77-6], trehalose dimycolate (TDM) [99-20-7], or the combination of MDP with TDM was studied by luminol-dependent chemiluminescence in response to stimulation by zymosan. Spleen cells from mice pretreated with TDM, but not those of mice treated with MDP, generated increased chemiluminescence. Spleen cells from animals pretreated with the combination of MDP and TDM exhibited markedly enhanced chemiluminescence activity. The effect of enhanced activity of prepns. contg. MDP combined with TDM was further examd. in vivo by an aerosol infection of pretreated mice with a mouse-pathogenic influenza virus. Pretreatment with 6-O-acyl analogs and one ubiquinone deriv. of MDP alone did not induce any resistance against influenza virus. Significant protection was conferred only when MDP and certain analogs were combined with TDM. The enhancement of nonspecific resistance to influenza virus infection was related to the chem. structure of the synthetic immunostimulant. A greater degree of protection was induced by the combination of TDM with the lipophilic derivs. like B 30-MDP and L-18 MDP.

Synthesis of an acryloyl-type polymer with pendent D-glucose analog of N-acetylmuramyl-L-alanyl-D-isoglutamine

Synthesis of an acryloyl-type polymer with pendent D-glucose analog of N-acetylmuramyl-L-alanyl-D-isoglutamine. Ouchi, Tatsuro; Sakamoto, Yoshiomi; Jokei, Satoshi; Chikashita, Hidenori (Fac. Eng., Kansai Univ., Suita 564, Japan). Makromol. Chem., 185(2), 255-62 (English) 1984. CODEN: MACEAK. ISSN: 0025-116X. DOCUMENT TYPE: Journal CA Section: 35 (Chemistry of Synthetic High Polymers) Section cross-reference(s): 33, 63 The title polymer (I) was synthesized as the lipophilic and polymeric model of 4-[N-[2-(2-acetylamino-2-deoxy-3-O-D-glucopyranosyl)propionyl]-L-ala nylamino]glutamic acid [53678-77-6] to the min. required structure for the immunoadjuvant activity of the bacterial cell wall. N-[2-(6-O-Acryloyl-1,2-O-isopropylidene-a-D-3-O-glucofuranosyl)prop ionyl]-L-alanine benzyl ester (II) [89989-64-0] was prepd. as a key monomer in the synthesis. The homopolymn. of II was carried out in benzene at 50° using 2,2'-azobisisobutyronitrile as radical initiator to give a homopolymer (III) [89989-67-3]. From the results of copolymn. with styrene [100-42-5] the values of Q and e for II were estd. to be 2.There are some commonly used reagents with their cas registry numbers 2051-76-5 and 100-42-5 in this article.0 and 0.11, resp. The removal of isopropylidene and benzyl protecting groups from III was carried out by acidic treatment with 6:1 (vol.) trifluoroacetic acid/water and by catalytic hydrogenolysis over Pd/C in acetone, resp., to afford I. .