Reference

Procedural and clinical studies of mexitil therapy

Procedural and clinical studies of mexitil therapy. Spectrophotofluorometric determination of the drug in blood plasma. Scheja, W.; Scheja, J. W.; Bruester, H. (Fachklin. Rhein/Ruhr Essen-Kettwig, Essen, Fed. Rep. Ger.). GIT Labor-Med., 6(1), 14-15, 18-20, 22-3, 26-8, 31-2 (German) 1983. CODEN: GLMDDD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A simple quant. spectrophotofluorimetric method for the detn. of mexitil (I) [5370-01-4] in plasma of patients, treated orally or i.v. with therapeutic doses of I, is described. Following alkalinization and ether extn. of the blood sample, I was obtained by reverse-extn. into a HCl-soln. The relative fluorescence max. of I is 218 nm. The recovery rate of I with this method is 95%, and the precision is 4.3%. The limit of detectability is 0.06 mg I/mL. This method was used to detn. the pharmacokinetics of I in humans.

Mexiletine hydrochloride

Mexiletine hydrochloride. Playle, A. C. (Spain). Med. Actual., 12(9), 358-65 (English/Spanish) 1976. CODEN: MDACAP. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacodynamics) A review with 3 refs. on the pharmacol. of mexiletine-HCl (I) [5370-01-4].