Reference

Enhancers for antimicrobial agents

Enhancers for antimicrobial agents. (Johnson and Johnson, USA). Japan. Kokai JP 53069833 21 Jun 1978 Showa, 25 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-045. APPLICATION: JP 76-141347 26 Nov 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 3 The effectiveness of antimicrobial agents can be enhanced by the addn. of: (1) primary, secondary or tertiary straight-chained or branched C￡17 alcs.; (2) I (R1 = C1-4 alkyl, halogen or H; R2 or R3 = H, C1-3 alkyl, cyclopropyl; n = 1-4); (3) II (m = 0 or 1; R4 = H, halogen, C1-4 alkyl or cyclopropyl; R5, R6, R7 = H, C1-3 alkyl or cyclopropyl) and (or) (4) III (R8 = H, C1-3 alkyl, C1-3 alkoxy, hydroxy, halogen, amino, or mono- or dialkylamino). E.g., a disinfectant contain 2,3-dimethyl-2-hexanol [19550-03-9] 3.0-10, antimicrobial agents 0.05-3.0, iso-PrOH 40.0, and propylene glycol 5.0% with distd. H2O added to make a final vol. of 100%. A prepn. contg. domiphen bromide [538-71-6] and 2,3-dimethyl-2-hexanol decreased the no. of Candida albicans in culture from 3.2 ′ 109 to 4.0 ′ 103 10 min after treatment, compared to 8.2 ′ 108 for a prepn. contg. domiphen bromide alone.

Potentiated medicaments

Potentiated medicaments.Some chemicals with cas registry numbers like 103-05-9 and 543-49-7 are also used. Sipos, Tibor (Johnson and Johnson, USA). U.S. US 4006218 1 Feb 1977, 10 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K007-22. NCL: 424054000. APPLICATION: US 72-285682 1 Sep 1972. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Antimicrobial compns. consisting of .gtoreq.0.001% of an antimicrobial agent and .gtoreq.0.05% of an alc. or phenolic potentiator in suitable carriers were described. Similar compns. contg. a local anesthetic and a penetration potentiator also were described. The pharmacol. evaluation of numerous compns. was reported. E.g., an antiplaque mouthrinse compn. contg. EtOH 20, glycerin 10, flavor 0.2, domiphen bromide [538-71-6] 0.05-0.10, 2-cyclohexylethanol [4442-79-9] 0.1-3.0, amaranth soln. 0.04, and distd. water to 100% reduced plaque formation 85-95%. .