Detail of "53808-88-1"

CAS Number:
53808-88-1
Name:
1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-
Molecular Structure:
Formula:
C17H13 Cl N2 O2
Molecular Weight:
0
Synonyms:
3-(4-Chlorophenyl)-1-phenylpyrazole-4-aceticacid; 3-(p-Chlorophenyl)-1-phenylpyrazole-4-acetic acid; Lonazolac
Density:
1.3g/cm³
Boiling Point:
525.1°Cat760mmHg
Flash Point:
271.4°C

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Column switching in HPLC - determination of drug substances in biological material: Column switching in HPLC - determination of drug substances in biological material. Arnold, P. J.; Guserle, R.; Woerz, Michaela; Luckow, V. (Merckle G.m.b.H. Pharmacokinet./Biopharm., Ulm D-7900, Fed. Rep. Ger.). Chromatographia, 22(7-12), 431 (English) 1986. CODEN: CHRGB7. ISSN: 0009-5893. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Optimum conditions are given for the detn. in biol. material of 4 substances with different polarity (pirenzepine [28797-61-7] and lonazolac [53808-88-1], mefloquine [53230-10-7], and pentoxifylline [6493-05-6] and their main metabolites) by HPLC with precolumn enrichment (by column switching) variously on RP2 25, Nucleosil C18, or Phenethyl. The limit of detection, recovery, and within-day precision are given. The method proved to be very flexible for adaptation to use in the detn. of different drugs.

Direct injection of biological fluids: application of HPLC-analysis with precolumn enrichment to the pharmacokinetic studies of lonazolac: Direct injection of biological fluids: application of HPLC-analysis with precolumn enrichment to the pharmacokinetic studies of lonazolac. Huber, R.; Zech, K.; Woerz, M.; Kronbach, T.; Voelter, W. 53808-88-1 and 89435-60-9 are also occured in this study. (Res. Lab., Byk Gulden Lomberg Chem. Fabr. G.m.b.H., Konstanz D-7750, Fed. Rep. Ger.). Chromatographia, 16, 233-6 (English) 1982. CODEN: CHRGB7. ISSN: 0009-5893. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Lonazolac (I) [53808-88-1] and its p-hydroxylated metabolite (M1) [89435-60-9] are detd. in serum by high performance liq. chromatog. using direct injection of comparatively large vols. with precolumn enrichment. No sample work-up is required prior to anal. Reproducibility, calibration plots, recoveries and detection limits are presented, together with various applications of the method. Data from direct injection of serum are also compared to results from a conventional extn. work-up. .