Reference

Sodium salicylate does not prevent the inhibitory effect of indomethacin on thromboxane formation in human blood ex vivo

Sodium salicylate does not prevent the inhibitory effect of indomethacin on thromboxane formation in human blood ex vivo. Dahl, Marja Liisa; Uotila, Pekka (Dep. Physiol., Univ. Turku, Turku SF-20520/52, Finland). Prostaglandins, Leukotrienes Med., 17(1), 71-6 (English) 1985. CODEN: PLMEDD. ISSN: 0262-1746. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Thromboxane formation during spontaneous blood clotting as well as plasma levels of TXB2 [54397-85-2] and 6-keto-PGF1a [58962-34-8], the stable metabolites of TXA2 [57576-52-0] and prostacyclin [35121-78-9], were measured by RIA 2 h after oral administration of indomethacin [53-86-1] (25 mg), Na salicylate [54-21-7] (250 mg), and their combination to human volunteers. Indomethacin suppressed the formation of TXB2 during blood clotting, whereas Na salicylate had only a slight inhibitory effect on TXB2 synthesis. The combination of indomethacin and Na salicylate inhibited TXB2 formation even slightly more effectively than indomethacin alone. Plasma TXB2 level was decreased after the combination treatment but not after administration of either of the drugs alone. Plasma 6-keto-PGF1a level was not changed by any of the treatments. Thus simultaneous oral administration of Na salicylate together with indomethacin at a combination ratio of does not significantly interfere with the inhibitory effects of indomethacin on thromboxane synthesis in human blood ex vivo.

Comparative study of methods to detect nitrates in water

Comparative study of methods to detect nitrates in water. Rooma, M.; Karlova, S. A. (Inst. Eksp. Klin. Med., Tallinn, USSR). Gig. Sanit., (2), 49-51 (Russian) 1985. CODEN: GISAAA. ISSN: 0016-9900. DOCUMENT TYPE: Journal CA Section: 61 (Water) Section cross-reference(s): 79 The following 4 methods for the detn. of NO3- in water were equally reliable (correlation coeffs. 0.9922-0.9984): (1) nitration of Na salicylate [54-21-7] and colorimetry, time 30 min, sensitivity 0.09 mg/L; (2) redn. of NO3- to NO2- by passage through a column contg. Cd and colorimetry, time 40 min, sensitivity 0.05 mg/L; (3) as above, but redn. with Zn, time 10 min, sensitivity 0.6 mg/L; and (4) potentiometric NO3- detn. in buffered soln. with the EM-NO3-01 electrode, time 2 min, sensitivity 2 mg in the water sample.