CAS No.54-25-1,6-AZAURIDINE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	54-25-1
Name:	6-AZAURIDINE
Article Data:	16

Formula:	C8H11 N3 O6
Molecular Weight:	245.192
Synonyms:	as-Triazine-3,5(2H,4H)-dione,2-b-D-ribofuranosyl- (6CI,7CI,8CI);2-b-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione;6-Azauracil 1-riboside; 6-Azauracil riboside; 6-Azauracil-b-D-riboside; 6-Azauridine;6-Azur; 6-Azuridine; AzUR; Azauridine; NSC 32074; Rib-Azauracil; Ribo-azuracil;Riboazauracil; ribo-Azauracil
EINECS:	200-199-6
Density:	2.08 g/cm³
Melting Point:	157-159 °C(lit.)
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Solubility:	It is soluble in water.
Hazard Symbols:	Xn
Risk Codes:	20/21/22-40
Safety:	Moderately toxic by intraperitoneal route. Human teratogenic effects by intravenous route: unspecified developmental abnormalities or effects on the embryo or fetus. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Used as an antineoplastic agent.
PSA:	137.67000
LogP:	-3.45690

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Chemistry

Molecular Formula: C₈H₁₁N₃O₆
Molar mass: 245.1894 g/mol
EINECS: 200-199-6
Density: 2.08 g/cm³
Index of Refraction: 1.795
Melting point: 157-159 °C(lit.)
Storage temp: 2-8°C
Product categories of 6-Azauridine (CAS NO.54-25-1): Biochemistry;Antibiotic Explorer;Nucleosides and their analogs;Pyridines, Pyrimidines, Purines and Pteredines;Nucleosides, Nucleotides & Related Reagents
Structure of 6-Azauridine (CAS NO.54-25-1):

XLogP3-AA: -2.1
H-Bond Donor: 4
H-Bond Acceptor: 7
IUPAC Name: 2-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione
Canonical SMILES: C1=NN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)
InChIKey: WYXSYVWAUAUWLD-UHFFFAOYSA-N

Toxicity Data With Reference

1.	sln-dmg-par 20 mmol/L	BCPCA6 Biochemical Pharmacology. 15 (1966),299.
2.	spm-rat-ipr 2 g/kg	CEFYAD Ceskoslovenska Fysiologie. 21 (1972),278.
3.	dni-mus-ipr 3 g/kg	NEOLA4 Neoplasma. 20 (1973),243.
4.	spm-mus-ipr 5 g/kg	CEFYAD Ceskoslovenska Fysiologie. 21 (1972),278.
5.	ivn-wmn TDLo:150 mg/kg (47D preg):TER	CLPTAT Clinical Pharmacology and Therapeutics. 7 (1966),162.
6.	ipr-rat LD50:9400 mg/kg	TJADAB Teratology, A Journal of Abnormal Development. 4 (1971),287.
7.	ipr-mus LD50:11,250 mg/kg	BCPCA6 Biochemical Pharmacology. 14 (1965),1517.
8.	ipr-dog LD50:3400 mg/kg	BCPCA6 Biochemical Pharmacology. 14 (1965),1537.
9.	ipr-cat LD50:2400 mg/kg	BCPCA6 Biochemical Pharmacology. 14 (1965),1537.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Moderately toxic by intraperitoneal route. Human teratogenic effects by intravenous route: unspecified developmental abnormalities or effects on the embryo or fetus. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Used as an antineoplastic agent.
Hazard Codes: Harmful Xn
Risk Statements:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R40:Limited evidence of a carcinogenic effect.
Safety Statements:
S22:Do not breathe dust.
S36:Wear suitable protective clothing.

Specification

6-Azauridine ,its cas register number is 54-25-1. It also can be called 6-Azauracil Ribozide ; ribo-Azauracil ; 2-(beta-D-Ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione ; 2-b-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione ; 2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H--[1,2,4]triazine-3,5-dione and 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl- .