Detail of "54-71-7"

Reference

Quantitative analysis of degradation products in pilocarpine hydrochloride ophthalmic formulations

Quantitative analysis of degradation products in pilocarpine hydrochloride ophthalmic formulations. Neville, George A.; Hasan, Fariza B.; Smith, Ian C. P. (Health Prot. Branch, Health Welfare Canada, Ottawa, Ont., Can.). J. Pharm. Sci., 66(5), 638-42 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The presence of isopilocarpine [531-35-1], an epimer of pilocarpine (I), and of pilocarpinic acid [28406-15-7], a hydrolytic degrdn. product of I, was established and all 3 substances were assayed in various com. ophthalmic formulations of I-HCl [54-71-7] by 13C-Fourier transform spectroscopy. Assay was based upon integrated intensities of selected resonances from any formulation calibrated against the intensity of tetramethylammonium bromide, used as a common external ref. The normalized intensities were then related to those of a ref. soln. of I-HCl, thereby eliminating any factor arising from variability of 13C-relaxation times. The 13C-resonance for the N-methyl group, being common to all products, provides a convenient basis for the assay of the total alkaloid content whereas the C-8 resonances are best suited for assaying residual I and its degrdn. products. This procedure, estd. as accurate to .+-.5%, constitutes the 1st comprehensive analytical method to differentiate between I and its degrdn. products.

Control of the pilocarpine release rate through hydrogels by plasma treatment

Control of the pilocarpine release rate through hydrogels by plasma treatment. Colter, K. D.; Bell, A. T.; Shen, M. (Sch. Med., Washington Univ., St. Louis, Mo., USA). Biomater., Med. Devices, Artif. Organs, 5(1), 1-12 (English) 1977. CODEN: BMDOAI. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Two treatments of polymer surface were tried to reduce the rate of release of an aq. soln. of pilocarpine-HCl (I-HCl) [54-71-7] sequestered in hydrogel-type materials (prepd. by photopolymn. of 2-hydroxyethyl methacrylate, and copolymn. of 2-hydroxyethyl methacrylate with Me acrylate. The 1st method involved exposure of the hydrogel to the effects of a glow discharge sustained in Ar, and the 2nd technique consisted of deposition of a thin film by (elec.) plasma polymn. of the gases, C2F4, C2H6, and C2F4. The 1st treatment was less effective than the 2nd in reducing I release. The most successful method was plasma polymn. of C2F4, with a film thickness of 0.25 .mu.m. Plasma-polymd. C2H6 and C2H4 films gave similar release rates. Polymn. conditions bringing about a crack-resistant film were crit. in obtaining the best results.