Reference

Animal experimental study of the problem of liver damage due to tuberculostatics (rifampicin and isoniazid) in addition to galactosamine models

Animal experimental study of the problem of liver damage due to tuberculostatics (rifampicin and isoniazid) in addition to galactosamine models. Leinweber, B.; Mahrt, R. (Zent. Inn. Med., Univ. Giessen, Giessen, Ger.). Verh. Dtsch. Ges. Inn. Med., 82(1), 300-3 (German) 1976. CODEN: VDGIA2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Rifampicin (I) [13292-46-1] (20 mg/kg), isoniazid (II) [54-85-3] (15 mg/kg) or I (10 mg/kg) + II (5 mg/kg) given orally to rats once or daily for 5 days produced no liver damage. Liver damage caused by galactosamine [7535-00-4] (400 mg/kg, i.p.) was potentiated by a single I dose; it was not potentiated by prolonged I administration or acute or chronic II administration.

Studies on the question of isoniazid (INH) effects on the distribution and metabolism of alcohol in people

Studies on the question of isoniazid (INH) effects on the distribution and metabolism of alcohol in people. Joachim, Hans; Bartscher, Karl Heinz; Rebholz, Klaus; Pohl, Klaus Dieter (Inst. Gerichtl. Med. Versicherungsmed., Univ. Freiburg, Freiburg/Br., Ger.). Blutalkohol, 11(4), 253-75 (German) 1974. CODEN: BLALAL. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 An increase in the blood alc. concn. (BAC) and a decrease in hematocrit were obsd. in test subjects given EtOH [64-17-5] (0.64 g/kg as brandy) and isoniazid (I) [54-85-3] (3 .times. 200 mg/day orally) compared to those given only EtOH. No significant increases in BAC were obsd. in subjects given beer and I. In spite of these results, however, no special consideration should be given in court to cases involving I-EtOH consumption.