CAS No.54-96-6,3,4-Diaminopyridine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	54-96-6
Name:	3,4-Diaminopyridine
Article Data:	16

Formula:	C₅H₇N₃
Molecular Weight:	109.131
Synonyms:	Pyridine, 3,4-diamino-;3,4-pyridinediamine;pyridine-3,4-diamine;3,4-DAP;Diamino-3,4 pyridine;1H-pyridine-3,4-diamine;5-22-11-00266 (Beilstein Handbook Reference);4,5-Diaminopyridine;3,4-Pyridinediamine (9CI);SC10;
EINECS:	200-220-9
Density:	1.251 g/cm³
Melting Point:	216-218 °C(lit.)
Boiling Point:	369.3 °C at 760 mmHg
Flash Point:	204.9 °C
Solubility:	water: 24 g/L (20 °C)
Appearance:	brownish to brown-grey crystalline powder
Hazard Symbols:	T+,T,Xi
Risk Codes:	25-26-36/37/38
Safety:	26-28-36/37/39-45-37/39-28A-36
Transport Information:	UN 2811 6.1/PG 2
PSA:	64.93000
LogP:	1.40840

Synthetic route

: 1681-37-4
4-amino-3-nitropyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 5250.42 Torr; for 20h; Hydrogenation;	98%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 10℃; under 760.051 Torr; for 24h;	97%
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 20℃;	97%

: 33544-42-2
3-nitro-4-hydrazinopyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 20 - 50℃; under 3102.9 Torr; for 2h;	94%

: 100306-70-5
4-(benzylamino)-3-nitropyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol at 80℃; under 3102.9 Torr; for 30h;	76%

: 504-24-5
4-aminopyridine

6-(2,6-dichlorophenyl)-2-methanesulfinyl(or sulfonyl)-8-methyl-8H-pyrido<2,3-d>pyrimidin-7-one: 6-(2,6-dichlorophenyl)-2-methanesulfinyl(or sulfonyl)-8-methyl-8H-pyrido<2,3-d>pyrimidin-7-one

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 97 percent / Et3N / acetonitrile / 1 h / 20 °C 2: 72 percent / N2O5 / nitromethane / 0.17 h / 0 °C 3: 96 percent / 2 M aq. HCl / 5 h / 70 °C 4: 98 percent / H2 / 5 percent Pd/C / methanol / 20 h / 20 °C / 5250.42 Torr View Scheme

: 5221-42-1
4-acetylaminopyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 72 percent / N2O5 / nitromethane / 0.17 h / 0 °C 2: 96 percent / 2 M aq. HCl / 5 h / 70 °C 3: 98 percent / H2 / 5 percent Pd/C / methanol / 20 h / 20 °C / 5250.42 Torr View Scheme

: 79371-42-9
N-(3-nitropyridin-4-yl)acetamide

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / 2 M aq. HCl / 5 h / 70 °C 2: 98 percent / H2 / 5 percent Pd/C / methanol / 20 h / 20 °C / 5250.42 Torr View Scheme

: 626-64-2
pyridin-4-ol

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 70 percent / fuming HNO3, fuming H2SO4 / 1,2-dichloro-ethane / 7 h / 80 - 82 °C 2: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 3: 90 percent / N2H4 / acetonitrile / 5 h / Heating 4: 94 percent / H2 / Raney Ni / ethanol / 2 h / 20 - 50 °C / 3102.9 Torr View Scheme
Multi-step reaction with 4 steps 1: 70 percent / fuming HNO3, fuming H2SO4 / 1,2-dichloro-ethane / 7 h / 80 - 82 °C 2: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 3: 87 percent / CH3COONH4 / H2O / 7 h / Heating 4: 85 percent / H2 / 5percent Pd/C / methanol / 1.5 h / 20 - 30 °C / 2585.7 Torr View Scheme
Multi-step reaction with 4 steps 1: 70 percent / fuming HNO3, fuming H2SO4 / 1,2-dichloro-ethane / 7 h / 80 - 82 °C 2: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 3: 163 g / ethanol / 18 h / Heating 4: 76 percent / H2 / 5percent Pd/C / ethanol / 30 h / 80 °C / 3102.9 Torr View Scheme

: 94602-04-7
4-ethoxy-3-nitropyridine hydrochloride

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / N2H4 / acetonitrile / 5 h / Heating 2: 94 percent / H2 / Raney Ni / ethanol / 2 h / 20 - 50 °C / 3102.9 Torr View Scheme
Multi-step reaction with 2 steps 1: 87 percent / CH3COONH4 / H2O / 7 h / Heating 2: 85 percent / H2 / 5percent Pd/C / methanol / 1.5 h / 20 - 30 °C / 2585.7 Torr View Scheme
Multi-step reaction with 2 steps 1: 163 g / ethanol / 18 h / Heating 2: 76 percent / H2 / 5percent Pd/C / ethanol / 30 h / 80 °C / 3102.9 Torr View Scheme

: 5435-54-1
4-hydroxy-3-nitropyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 2: 90 percent / N2H4 / acetonitrile / 5 h / Heating 3: 94 percent / H2 / Raney Ni / ethanol / 2 h / 20 - 50 °C / 3102.9 Torr View Scheme
Multi-step reaction with 3 steps 1: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 2: 87 percent / CH3COONH4 / H2O / 7 h / Heating 3: 85 percent / H2 / 5percent Pd/C / methanol / 1.5 h / 20 - 30 °C / 2585.7 Torr View Scheme
Multi-step reaction with 3 steps 1: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 2: 163 g / ethanol / 18 h / Heating 3: 76 percent / H2 / 5percent Pd/C / ethanol / 30 h / 80 °C / 3102.9 Torr View Scheme

: 504-24-5
4-aminopyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; potassium nitrate / 6.5 h / 10 - 65 °C 2: sodium sulfide / methanol; water / 0 - 65 °C View Scheme

Raw Materials

504-24-5

626-64-2

Downstream Products

254-86-4

Total:168 Page 1 of 5 1 2 3 4 5 Next>>

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Chemistry

Molecular Structure of 3,4-DIAMINOPYRIDINE(54-96-6):

IUPAC Name:pyridine-3,4-diamine
Molecular Formula:C₅H₇N₃
Molecular Weight:109.129180 g/mol
Appearance:light brown crystalline powder
Melting Point:216-218 °C(lit.)
Density:1.251 g/cm³
Flash Point:204.9 °C
Enthalpy of Vaporization:61.61 kJ/mol
Boiling Point:369.3 °C at 760 mmHg
Vapour Pressure:1.2E-05 mmHg at 25 °C
Water Solubility:8.292e+005 mg/L at 25 °C
Merck:14,2986
BRN:110232
EINECS:200-220-9
Synonyms of 3,4-DIAMINOPYRIDINE(54-96-6):
3,4-diamino-pyridin;3,4-pyridinediamine;4,5-diaminopyridine;diamino-3,4pyridine;TIMTEC-BB SBB004341;PYRIDINE-3,4-DIAMINE;DIAMINOPYRIDINE(3,4-);ASINEX-REAG BAS 01447204
Categories of 3,4-DIAMINOPYRIDINE(54-96-6):
Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Pyridines;Boronic Acid

Toxicity Data With Reference

1.	ipr-mus LD50:20 mg/kg	JMCMAR Journal of Medicinal Chemistry. 8 (1965),296.
2.	scu-mus LD50:35 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 150 (1964),413.
3.	ivn-mus LD50:13 mg/kg	APFRAD Annales Pharmaceutiques Francaises. 26 (1968),345.
4.	orl-bwd LD50:75 mg/kg	AECTCV Archives of Environmental Contamination and Toxicology. 12 (1983),355.

Safety Profile

Safety Information of 3,4-DIAMINOPYRIDINE(54-96-6):
Hazard Codes:T+,T

,Xi

Risk Statements:25-26-36/37/38
Safety Statements:26-28-36/37/39-45-37/39-28A-36
RIDADR:UN 2811 6.1/PG 2
WGK Germany:3
RTECS:US7600000
F:10-23
Hazard Note:Irritant
HazardClass:6.1
PackingGroup:I
HS Code:29333999
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x.

Specification

First Aid Measures of 3,4-DIAMINOPYRIDINE(54-96-6):
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid immediately. Wash mouth out with water.
Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Storage of 3,4-DIAMINOPYRIDINE(54-96-6):
Store in a cool, dry place. Store in a tightly closed container.