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540-23-8

Basic Information
CAS No.: 540-23-8
Name: 4-Methylaniline hydrochloride
Article Data: 35
Molecular Structure:
Molecular Structure of 540-23-8 (4-Methylaniline hydrochloride)
Formula: C7H9 N . Cl H
Molecular Weight: 143.616
Synonyms: Benzenamine,4-methyl-, hydrochloride (9CI); p-Toluidine, hydrochloride (8CI);4-Aminotoluene hydrochloride; 4-Methylaniline hydrochloride; 4-Methylaniliniumchloride; 4-Methylbenzenamine hydrochloride; 4-Methylphenylammonium chloride;p-Methylaniline hydrochloride; p-Methylanilinium chloride; p-Toluidiniumchloride
EINECS: 208-740-8
Density: 1.193 g/cm3
Melting Point: 243-245 ºC
Boiling Point: 200.4oC
Solubility: Soluble in water
Appearance: white to light beige crystalline powder, crystals
Hazard Symbols:
Risk Codes: R23/24/25;R36;R40;R43;R50   
Safety: Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also p-TOLUIDINE.
PSA: 26.02000
LogP: 2.96040
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Chemistry

MF: C7H10ClN
MW: 143.61
EINECS: 208-740-8
Flash Point: 84.5 °C 
Melting Point:243-245 ºC
Enthalpy of Vaporization: 43.36 kJ/mol 
Vapour Pressure: 0.379 mmHg at 25°C   
IUPAC Name: 4-methylaniline hydrochloride
Boiling Point of P-Toluidine hydrochloride (540-23-8): 197.4 °C at 760 mmHg
Synonyms: 4-methylaniliniumchloride ; 4-methylbenzenaminehydrochloride ; 4-methyl-benzenaminhydrochloride ; p-methylaniliniumchloride ; 4-Toluidine hydrochloride ; 4-Amino-1-methylbenzene hydrochloride ; 4-Aminotoluene hydrochloride ; 4-Methylaniline hydrochloride
Following is the molecular structure of P-Toluidine hydrochloride (540-23-8):

Toxicity Data With Reference

1.    

orl-rat LD50:1285 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 167 (1969),223.
2.    

ipr-rat LD50:265 mg/kg

    NCIBR*    Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) NCI-E-68-1311 ,1973.
3.    

ipr-mus LD50:399 mg/kg

    NCIBR*    Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) NCI-E-68-1311 ,1973.

Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Safety Information of P-Toluidine hydrochloride (540-23-8):
Hazard Codes: T,N
T: Toxic N: Dangerous for the environment  
Risk Statements: 23/24/25-36-40-43-50
23/24/25:  Toxic by inhalation, in contact with skin and if swallowed 
36: Irritating to the eyes 
40: Limited evidence of a carcinogenic effect  
43: May cause sensitization by skin contact  
50: Very Toxic to aquatic organisms   
Safety Statements: 28-36/37-45-61
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 
36/37: Wear suitable protective clothing and gloves 
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
61: Avoid release to the environment. Refer to special instructions safety data sheet 
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: XU7525000
HazardClass: 6.1(a)
PackingGroup: II