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CAS No.: | 54143-55-4 |
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Name: | Flecainide |
Molecular Structure: | |
Formula: | C17H20F6N2O3 |
Molecular Weight: | 414.348 |
Synonyms: | benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-;Flecaine;N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide;N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide;Benzamide,N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-; |
EINECS: | 258-997-5 |
Density: | 1.286 g/cm3 |
Melting Point: | 105-107 °C |
Boiling Point: | 434.9 °C at 760 mmHg |
Flash Point: | 216.8 °C |
Appearance: | White crystalline powder |
Hazard Symbols: | F,T |
Risk Codes: | 11-23/24/25-39/23/24/25 |
Safety: | 7-16-36/37-45 |
PSA: | 59.59000 |
LogP: | 4.16040 |
1. Introduction of Flecainide
Flecainide, as one kind of white crystalline powder, odorless, little bitter taste, belongs to the Product Categories which include Intermediates & Fine Chemicals; Pharmaceuticals.
2. Toxicity of Flecainide
Due to the narrow therapeutic index of flecainide, physicians should be alert for signs of toxicity before life-threatening arrhythmias occur like torsade de pointes. While the toxic effects of flecainide are closely related to the plasma levels of the drug,it is infeasible to check the plasma concentration in an individual on a regular basis.Signs of flecainide toxicity include marked prolongation of the PR interval and widening of the QRS duration on the surface ECG. There may be signs and symptoms attributable to overt heart failure secondary to sudden decreased myocardial contractility.
3. Safety Information of Flecainide
Human systemic effects. When heated to decomposition it emits toxic vapors of NOx and F−.
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
4. Use of Flecainide
Flecainide is used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart). It is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation (episodic irregular heartbeat originating in the upper chamber of the heart), paroxysmal supraventricular tachycardia, and ventricular tachycardia (rapid rhythms of the lower chambers of the heart).