Reference

Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity

Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity. Jansen, Michaela; Dannhardt, Gerd (Institute of Pharmacy, Department of Medicinal and Pharmaceutical Chemistry, Johannes Gutenberg-University, Mainz 55099, Germany). European Journal of Medicinal Chemistry, 38(10), 855-865 (English) 2003 Elsevier Science Ltd. CODEN: EJMCA5. ISSN: 0223-5234.Some commonly used reagents like 5416-93-3 and 194490-19-2 are used in this experiment. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 The synthetic procedures to obtain indole derivs. with different acidic functions at position 2 of the indole are reported. The synthesized and tested derivs. comprise 5-tetrazolyl, 1,3,4-oxadiazol-5-yl-2-one, and indole-2-carboxylic acid amides with 5-aminotetrazole, methanesulfonamide and trifluoromethanesulfonamide moieties. The binding affinity was evaluated using [3H]MDL 105,519 and pig cortical brain membranes. In general, compds. with acidic functions different from a carboxylic acid moiety are less potent than indole-2-carboxylic acid derivs. Also, the 4,6-dichloro substitution pattern was compared to 5-tert-Bu derivs. and compds. not substituted in the benzene moiety of the indole, indicating that the affinity increases from 5-tert-Bu over unsubstituted to 4,6-dichloro substituted derivs. .

Phenylcarbamoylimidazolines and their use as pecticides

Phenylcarbamoylimidazolines and their use as pecticides. (Wellcome Foundation Ltd., UK). Israeli IL 57595 A1 30 Sep 1983, 34 pp. Addn. to Israeli 53,640. (English). (Israel). CODEN: ISXXAQ. CLASS: IC: C07D233-20; A01N047-38. APPLICATION: IL 79-57595 19 Jun 1979. PRIORITY: IL 77-53640 19 Dec 1977; GB 78-27295 19 Jun 1978. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 5 The title imidazolines I (R = alkyl, alkoxy, halo, cyano, NO2, CO2R1, SO2NR2R3; R1-R3 = alkyl; Z = NH, O) were prepd. by carbamoylation of imidazolines. Thus, 2-[(2,3-dimethylanilino)methyl]-2-imidazoline was treated with 4-ClC6H4NCO to give I (R = Cl, Z = NH) (II). 5416-93-3 and 67400-54-8 which are cas registry numbers of substances are two of reagents here. At 0.029% II gave 99% inhibition of egg laying by Boophilus microplus. .