Detail of "5418-95-1"

Reference

Inhibitory effects of 2-guanidinebenzimidazole and 1-phenylbiguanide on gastric acid secretion in rats

Inhibitory effects of 2-guanidinebenzimidazole and 1-phenylbiguanide on gastric acid secretion in rats. Pinelli, A.; Colombo, R.; Trivulzio, S.; Berti, F.; Tofanetti, O.; Caimi, B. R. (Dep. Pharmacol., Univ. Milan, Milan, Italy). Arzneim.-Forsch., 34(8), 890-4 (English) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The antihistaminic effects of 2-guanidinebenzimidazole (GBI)(I) [5418-95-1] and 1-phenylbiguanide (PBB)(II) [102-02-3] on betazole stimulated gastric acid secretion were confirmed by the inhibitory activity of these compds. on the isolated guinea pig auricle stimulated by histamine. The antimuscarinic activity of GBI and PBG on carbacholstimulated gastric acid secretion in rats is supported by the way in which these same drugs depress the motility of the duodenum and colon of the anesthetized cat stimulated by prostigmine. The above mentioned effects of these compds. are also assocd. with myolytic activity, since they decrease the spontaneous with myolytic activity, since they decrease the spontaneous and histamine-stimulated motility of the duodenum and colon. GBI and PBG probably depress gastric acid secretion by interfering with both histamine and acetylcholine receptors and with other sites involved in the secretory process. GBI and PBG appear to be capable of decreasing gastric acid secretion, while the compds. dimethylbiguanide [657-24-9] and cyanoguanidine [461-58-5] do not. Thus, the antisecretory effect is present when the biguanide groups are assocd. with lipophilic mols.

Heterocyclic guanidine-alkyl compounds for use as motor fuel and lubricant additives

Heterocyclic guanidine-alkyl compounds for use as motor fuel and lubricant additives. Cohen, Choua; Sillion, Bernard (Institut Francais du Petrole, des Carburants et Lubrifiants, Fr.). Ger. Offen. DE 2539381 18 Mar 1976, 17 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D; C10M. PRIORITY: FR 74-30819 10 Sep 1974. DOCUMENT TYPE: Patent CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) Section cross-reference(s): 28, 37 Detergent-dispersant additives are prepd. by alkylation of heterocyclic guanidines. Thus, 2-benzimidazolylguanidine [5418-95-1] was alkylated with chlorinated polyisobutylene (mol. wt. 960; 4 wt.% Cl) at 200.degree. for 4 h. The product (contg. 1.4 wt.% N and 0.2 wt.% Cl), added to a lubricating oil at 2 wt.%, had better dispersant properties than conventional alkylsuccinimide dispersants, and showed good detergent characteristics in the Petter AVI engine test. Similarly alkylated and used were 2-benzothiazolylguanidine [2582-07-2], 2-benzoxazolylguanidine [39123-82-5], and 2-(4(3H)-oxoquinazolinyl)guanidine [62936-92-9]. The same dispersants were also effective in gasolines at 200 ppm.