Detail of "5424-19-1"

Reference

Flavoring agent

Flavoring agent. Winter, Max; Gautschi, Fritz; Flament, Ivon; Stoll, Max (Firmenich S. A., Switz.). U.S. US 4018910 19 Apr 1977, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A23L001-234. NCL: 426537000. APPLICATION: US 65-452342 30 Apr 1965. DOCUMENT TYPE: Patent CA Section: 17 (Foods) Section cross-reference(s): 27 The flavor of coffee may be modified by the addn. of a small amt. of a pyridine compd. contg. a carbonyl group. The flavor characteristics of 2-acetylpyridine [1122-62-9], 3-acetylpyridine [350-03-8], 4-acetylpyridine [1122-54-9], 6-methyl-2-acetylpyridine [6940-57-4], pyridine-2-aldehyde [1121-60-4], pyridine-3-aldehyde [500-22-1], pyridine-4-aldehyde [872-85-5], 6-methylpyridine-2-aldehyde [1122-72-1], 2-benzoylpyridine [91-02-1], 3-benzoylpyridine [5424-19-1], 4-benzoylpyridine [14548-46-0], 2,6-diacetylpyridine [1129-30-2], and 4-(.gamma.-pyridyl)butan-2-one (I) [35250-71-6] are tabulated. I was prepd. by holding 2 mL 2N NaOH, 10.8 g pyridine-4-aldehyde, 100 mL H2O, and 10 mL Me2CO at 12-15.degree. for 3 min, neutralizing with 10% HOAc, satg. with NaCl, and extg. with Et2O. The Et2O was distd. to give 8.4 g 4-(.gamma.-pyridyl)-3-buten-2-one [10416-53-2], yellow oil b0.07 135-8.degree.. Soln. of the oil in 30 mL EtOH, hydrogenation over Ni catalyst, and distn. of the product gave I, b0.05 83-5, n427 1.047, nD27 1.516.

The metabolism of 3-benzoylpyridine

The metabolism of 3-benzoylpyridine. Eyer, P.; Hell, W. (Med. Fak., Ludwig-Maximilians-Univ. Muenchen, Munich D-8000/2, Fed. Rep. Ger.). Xenobiotica, 13(11), 649-59 (English) 1983. CODEN: XENOBH. ISSN: 0049-8254. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) 3-Benzoylpyridine (3-BP)(I) [5424-19-1], a decompn. product of the soman antidote, HGG 12 [65320-89-0] was rapidly metabolized in the isolated perfused rat liver, giving 3-(a-hydroxybenzyl)pyridine [6270-47-9] and its corresponding glucuronide [89426-86-8], 3-benzoylpyridine N-oxide [29022-36-4], and 3-(a-hydroxybenzyl)pyridine N-oxide [39585-76-7]. The latter is formed both from 3-(a-hydroxybenzyl)pyridine and 3-benzoylpyridine N-oxide. Metab. of 3-BP studied in rats and dogs in vivo revealed species differences. In rat, 80% of [14C]3-BP was excreted in urine mostly as the glucuronide of 3-(a-hydroxybenzyl)pyridine and as the quaternary pyridinium compds., 3-benzoyl-1-methylpyridinium [38495-55-5] and 3-(a-hydroxybenzyl)-1-methylpyridinium [89426-85-7]. These latter were hardly detected in rat urine.In this experiment, several chemicals are used like 89426-85-7 and 39585-76-7 In contrast to rats, the N-oxides were present only in small amts. in dog urine. .