Detail of "54256-33-6"

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Cephalosporin analogs

Cephalosporin analogs.There are some reagents like 54256-33-6 is used in this study. (Beecham Group Ltd., Engl.). Japan. Kokai JP 51149295 22 Dec 1976 Showa, 29 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D487-04. PRIORITY: GB 75-19744 10 May 1975. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) I (R, R1 = PhOCH2, Me; PhOCH(CO2Ph), Me; PhCHOH, CH2Ph) were prepd. from II in 9 steps. I are bactericides. Ring cleavage of II (R = PhOCH2) by (AcO)2Hg in AcOH gave III [R2 = C(CO2Me):CMe2, R3 = CO2Me, R4 = PhOCH2CONH(Q)], KMnO4 oxidn. of which gave III (R2 = H, R3 = CO2Me, R4 = Q). This was treated with (AcO)2Zn and HCYCCH2OH to give III (R2 = H, R3 = OCH2CYCH, R4 = Q), which was reacted with tert-Bu glyoxylate to give III [R2 = CH(OH)CO2CMe3, R3, R4 as above] (IV). IV and SOCl2 gave III (R2 = CHClCO2CMe3, R3, R4 as above), which was treated with PPh3 to give III [R2 = C(:PPh3)CO2CMe3, R3, R4 as above] (V). Reaction of V with HgCl2 in piperidine gave III (R3 = OCH2Ac, R2, R4 as above), which was cyclized by refluxing 16 h in dioxane to give the tert-Bu ester of I (R = PhOCH2, R1 = Me), followed by hydrolysis to give I (R = PhOCH2, R1 = Me). 54256-33-6 is just another one chemical used in this study. ..

Cephalosporin analogs

Cephalosporin analogs.There are some reagents like 54256-33-6 is used in this study. (Beecham Group Ltd., Engl.). Japan. Kokai JP 51149295 22 Dec 1976 Showa, 29 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D487-04. PRIORITY: GB 75-19744 10 May 1975. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) I (R, R1 = PhOCH2, Me; PhOCH(CO2Ph), Me; PhCHOH, CH2Ph) were prepd. from II in 9 steps. I are bactericides. Ring cleavage of II (R = PhOCH2) by (AcO)2Hg in AcOH gave III [R2 = C(CO2Me):CMe2, R3 = CO2Me, R4 = PhOCH2CONH(Q)], KMnO4 oxidn. of which gave III (R2 = H, R3 = CO2Me, R4 = Q). This was treated with (AcO)2Zn and HCYCCH2OH to give III (R2 = H, R3 = OCH2CYCH, R4 = Q), which was reacted with tert-Bu glyoxylate to give III [R2 = CH(OH)CO2CMe3, R3, R4 as above] (IV). IV and SOCl2 gave III (R2 = CHClCO2CMe3, R3, R4 as above), which was treated with PPh3 to give III [R2 = C(:PPh3)CO2CMe3, R3, R4 as above] (V). Reaction of V with HgCl2 in piperidine gave III (R3 = OCH2Ac, R2, R4 as above), which was cyclized by refluxing 16 h in dioxane to give the tert-Bu ester of I (R = PhOCH2, R1 = Me), followed by hydrolysis to give I (R = PhOCH2, R1 = Me). 54256-33-6 is just another one chemical used in this study. ..