Reference

Glutamine derivatives as immunoregulators

Glutamine derivatives as immunoregulators. (Nippon Shinyaku Co., Ltd.; Mitsubishi Chemical Industries Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58194813 A2 12 Nov 1983 Showa, 8 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-19; A61K031-165; A61K031-215. APPLICATION: JP 82-78891 11 May 1982. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 15, 34 The glutamine derivs. I (R1 = R2 = Z = H or lower alkyl) were prepd. There are some commonly used reagents like 3705-42-8 in this article. as immunoregulators. Thus, N-carbobenzoxy-L-glutamic acid a-benzyl ester [3705-42-8] was treated with iso-Bu chlorocarbonate [543-27-1], followed by Et 2-(4-aminophenyl)butyrate [57960-84-6]. The product was then hydrogenated in the presence of Pd to give N-4-(1-ethoxycarbonylpropyl)phenyl-L-glutamine [83397-47-1]. The efficacy of this product for the treatment of allergy was demonstrated in mice. .

Monoclonal antibodies conjugated with a metal chelate for cancer treatment

Monoclonal antibodies conjugated with a metal chelate for cancer treatment. Gansow, Otto A.; Strand, Mette (USA ). Fr. Demande FR 2527928 A1 9 Dec 1983,32 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: A61K043-00; A61K039-395. ICA: C12N005-00. APPLICATION: FR 83-9437 7 Jun 1983. PRIORITY: US 82-386109 7 Jun 1982; US 82-386110 7 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 15 Monoclonal antibodies conjugated with a metal chelate are useful for the treatment of cancer. A soln. of DTPA [67-43-6] in water was treated with Et3N and product lyophilized to yield a solid. This product was converted to DTPA mixed anhydride on treatment with iso-Bu chloroformate [543-27-1]. A monoclonal antibody 103A5, prepd. by std. 67-43-6 and 89319-70-0 are cas registry numbers of chemicals which are used as reagents here. techniques by the fusion of rat myeloma cells P3K63Ag8 with rat C56B116 cells, was treated with the mixed anhydride in 0.1M NaHCO3 soln. and the soln. dialyzed against a soln. contg. ascorbic acid, EDTA, NaCl and Na citrate. A monoclonal antibody conjugated with a chelate was obtained and contained 1.5 chelate/mol of the antibody. This was labeled with 111InCl and purified by Sephadex G-50 chromatog. The antibody retains practically 100% of its biol. activity and its specificity in in vitro tests. .