Reference

Effects of multiple putative anticarcinogens on the carcinogenicity of trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole

Effects of multiple putative anticarcinogens on the carcinogenicity of trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole. Dunsford, Harold A.; Dolan, Patrick M.; Seed, John L.; Bueding, Ernest (Health Sci. Cent., Univ. Texas, Houston, TX 77030, USA). JNCI, J. Natl. Cancer Inst., 73(1), 161-8 (English) 1984. CODEN: JJIND8. ISSN: 0198-0157. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4, 14, 18 In an attempt to dissoc. the chemotherapeutic from the carcinogenic properties of the antischistosomal and antitrypanosomal nitrovinylfuran SQ 18506 (trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole) [28754-68-9], potential inhibitors of carcinogenesis were administered to female outbred CD-1 mice before and during exposure to SQ18506. The compds. tested were ascorbic acid [50-81-7], etretinate [54350-48-0], butylated hydroxyanisole (BHA) [25013-16-5], cysteamine [60-23-1], cysteine [52-90-4] dimercaprol [59-52-9], disulfiram [97-77-8], 1,4-dithiothreitol [3483-12-3], reduced glutathione [70-18-8], and spermidine [124-20-9]. The primary types of tumors obsd. were squamous cell carcinomas of the stomach and thymic and nonthymic lymphomas. BHA reduced the incidence of malignant tumors to control levels, whereas cysteine hydrochloride, spermidine phosphate, and disulfirmam reduced the incidence of chem. induced tumors by 42, 34, and 32%, resp. Although cysteamine and disulfiram had no or only a modest effect on the overall incidence of tumors, the data suggested possible tissue-specific anticarcinogenic properties for these agents. Of the 8 antioxidants tested, only 1 had marked anticarcinogenic properties against SQ18506. These data indicate that antioxidant properties alone cannot account for the anticarcinogenic activity of the compds. tested. Coadministration of the anticarcinogen BHA with SQ18506 also blocked the chemotherapeutic effects of this agent on female CD-1 mice infected with Schistosoma mansoni.

Anti-inflammatory effects of the retinoids

Anti-inflammatory effects of the retinoids. Bradshaw, D.; Cashin, C. H.; Kennedy, A. J. (Dep. Pharmacol., Roche Prod. Ltd., Welwyn Garden City/Herts. AL7 3AY, UK). Retinoid Ther., Proc. Int. Conf., Meeting Date 1983, 335-43. Edited by: Cunliff, William James; Miller, Allan John. MTP: Lancaster, UK. (English) 1984. CODEN: 52DXAR. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Orally administered etretinate (I) [54350-48-0], isotretinoin (II) [4759-48-2], and motretinide (III) [56281-36-8] displayed antiinflammatory activity in animal models of inflammation (1) delayed hypersensitivity test in the mouse; 2) adjuvant polyarthritis test in the rat; and 3) carrageenan-induced pleurisy in the rat). I showed significant activity in all 3 tests. II did not show significant activity in the delayed hypersensitivity test, whereas III showed its greatest activity in this particular test. The mechanisms of action of retinoids in reducing inflammation are discussed.