Detail of "54397-85-2"

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CAS Number:
54397-85-2
Name:
5-Heptenoic acid,7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2H-pyran-3-yl]-,(5Z)-
Molecular Structure:
Formula:
C₂₀H₃₄O₆
Molecular Weight:
370.48
Synonyms:
5-Heptenoicacid, 7-[(2R,3S,4S)-tetrahydro-4,6-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octenyl]-2H-pyran-3-yl]-,(5Z)- (9CI);Thromboxa-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,13E,15S)-;8-(1-Hydroxy-3-oxopropyl)-9,12-dihydroxy-5,10-heptadecadienoic acid hemiacetal;Thromboxane B2;(5Z,9α,11RS,13E,15S)-9,11,15-Trihydroxythromboxa-5,13-dien-1-oic acid;(5Z,13E,15S)-9α,11,15-Trihydroxythromboxa-5,13-dien-1-oic acid;
Density:
1.171 g/cm³
Boiling Point:
582.5 °C at 760 mmHg
Flash Point:
199.7 °C
Hazard Symbols:
Xn
Risk Codes:
63
Safety:
22-36 Details

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Metabolism and action of the prostaglandin endoperoxide PGH2 in rat kidney: Metabolism and action of the prostaglandin endoperoxide PGH2 in rat kidney. Zenser, Terry V.; Herman, Ceil A.; Gorman, Robert R.; Davis, Bernard B. (Geriatr. Cent., VA Hosp., St. Louis, Mo., USA). Biochem. Biophys. Res. Commun., 79(2), 357-63 (English) 1977. CODEN: BBRCA9. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Kidney membrane fractions metabolized 14C-labeled PGH2 (I) [42935-17-1] to thromboxane B2 [54397-85-2], PGE2 [363-24-6], PGF2a [551-11-1], PGD2 [41598-07-6], 6-keto PGF1a [58962-34-8], and 12L-hydroxy-5,8,10-heptadecatrienoic acid [54397-84-1]. Thromboxane A2 [57576-52-0], as measured by thromboxane B2, was enzymatically formed in cortex microsomes and was identified by thin layer chromatog. and gas chromatog.-mass spectrometry. PGH2 caused a labile inhibition of cortical PGE2-stimulated adenylate cyclase [9012-42-4]. The inability of 2 thromboxane synthetase inhibitors, imidazole and 9,11-azoprosta-5,13-dienoic acid, to block PGH2 inhibition suggest that thromboxane A2 is not an obligatory intermediate in this process. Therefore, a potential function of cortical PGH2 is inhibition of adenylate cyclase.

Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes: Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes. Ali, M.; Zamecnik, J.; Cerskus, A. L.; Stoessl, A. J.; Barnett, W. H.; McDonald, J. W. D. (Dep. Biochem., Univ. West. Ontario, London, Ont., Can.). Prostaglandins, 14(5), 819-27 (English) 1977. CODEN: PRGLBA. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Bovine gastric mucosal microsomes synthesized prostaglandins from arachidonic acid, but thromboxane B2 [54397-85-2] was the principal product. Thromboxane B2 synthesis occurred at an appreciable rate from endogenous precursor, but more rapidly with added arachidonate. Nonsteroidal antiinflammatory drugs inhibited synthesis of prostaglandins and thromboxanes with the following decreasing order of potency: indomethacin [53-86-1], fenoprofen [31879-05-7], acetylsalicylic acid [50-78-2], phenylbutazone [50-33-9], sulfinpyrazone [57-96-5] and acetaminophen [103-90-2].