Reference

Validation of a simple liquid chromatography-tandem mass spectrometric method for the determination of propiverine hydrochloride and its N-oxide metabolite in human plasma

Validation of a simple liquid chromatography-tandem mass spectrometric method for the determination of propiverine hydrochloride and its N-oxide metabolite in human plasma. Komoto, Ikumi; Yoshida, Ken-ichiro; Matsushima, Eiji; Yamashita, Kazumasa; Aikawa, Tsutomu; Akashi, Shunji (Pharmacokinetics Research Laboratory, Taiho Pharmaceutical Co. Ltd., Hiraishi, Kawauchi-cho, Tokushima 771-0194, Japan). Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 799(1), 141-147 (English) 2004 Elsevier B.V. CODEN: JCBAAI. ISSN: 1570-0232. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A simple HPLC-tandem mass spectrometric method was developed for detn. of propiverine hydrochloride and its metabolite, propiverine N-oxide (M-1) in human plasma using stable isotopes, propiverine hydrochloride-d10 and M-1-d10, as internal stds. The analytes were extd. with CH2Cl2 from 0. 111071-96-6 and 54556-98-8 which are cas registry numbers are also used here.2 mL of plasma in neutral condition (pH 7.0) and sepd. by HPLC on a C18 reversed-phase column using MeOH-1% HOAc () as a mobile phase, and detected using pos. electrospray ionization in selected reaction monitoring (SRM) mode. The method was validated over a concn. range of 2-500 ng/mL for propiverine hydrochloride and 4-1000 ng/mL for M-1 using 0.2 mL of human plasma per assay. The method developed was successfully applied to anal. of propiverine hydrochloride and M-1 in clin. studies. .

Propiverine hydrochloride immediate (IR) and extended release (ER): comparison of efficacy and tolerability in patients with overactive bladder

Propiverine hydrochloride immediate (IR) and extended release (ER): comparison of efficacy and tolerability in patients with overactive bladder. Juenemann, K.; Hessdoerfer, E.; Unamba-Oparah, I.; Berse, M.; Bruenjes, R.; Madersbacher, H.; Gramatte, T. (Dept.. Urology, Univ Hosp Kiel, Germany). Neurourology and Urodynamics, 23(5/6), 599-600 (English) 2004 Wiley-Liss, Inc. CODEN: NEUREM. ISSN: 0733-2467. 54556-98-8 which is the cas registry number of one of substances is just one of reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The efficacy of propiverine hydrochloride immediate release (IR) and propiverine hydrochloride extended release (ER) in comparison with placebo in patients with overactive bladder was evaluated. Propiverine IR and propiverine ER reduce incontinence, urge and no. of micturations in patients with overactive bladder syndrome. .