Reference

Sulfonamide-potentiator solutions

Sulfonamide-potentiator solutions. Stoll, Klaus; Franz, Helmut (Saarstickstoff-Fatol G.m.b.H., Ger.). Ger. Offen. DE 2627706 22 Dec 1977, 16 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-63. APPLICATION: DE 76-2627706 21 Jun 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Stable water-miscible solns. of sulfonamide-potentiator (pyrimidine deriv.) combinations contg. 5-10 wt. % of the active ingredient are prepd. in glycerin formal [5464-28-8] with addn. of (a) 20-50% ethanol [64-17-5] and/or (b) 4-10% poly(vinylpyrrolidone) [9003-39-8] and/or (c) 4-10% of a neutral mixt. of a salt of an org. acid with the free acid and/or (d) alkanolamine to provide a pH of 6.5-7.5. The stability is increased by adding an ethylene oxide-propylene oxide block copolymer such as Pluronic F68 [9003-11-6]. For example, a soln. for oral administration was prepd. contg. sulfamethoxazole (I) [723-46-6] 4.000, trimethoprim (II) [738-70-5] 0.800, glycerin formal 48.600, EtOH 17.400, Pluronic F68 2.000, Na saccharin 0.500, Na cyclamate 1.500, anise oil 0.030, NaCl 0.030 g, and water to 100 mL.

Separation and determination of the two components of glycerol formal by high-performance liquid chromatography

Separation and determination of the two components of glycerol formal by high-performance liquid chromatography. Pivnichny, James V. (Merck Sharp and Dohme Res. Lab., Rahway, NJ 07065, USA). J. Pharm. Biomed. Anal., 2(3-4), 491-500 (English) 1984. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The 2 isomeric components of glycerol formal, 1,3-dioxan-5-ol (I) [4740-78-7], and 1,3-dioxolane-4-methanol (II) [5464-28-8] are marginally sepd. (Rs = 1.0) by polar-bonded-phase HPLC on a cyanopropyl column with Me2CO-hexane as the eluent. Esterification of these components with 3,2-dinitrobenzoyl chloride [99-33-2] produces derivs. which are, however, completely resolved (Rs > 2) by the normal-phase HPLC on silica; derivatization has the added advantage of introducing an UV-absorbing chromophore into each component. Preparative scale chromatog. is used to isolate each of the derivs., which are characterized by their UV, NMR and mass spectra. These esters are used as ref. std. for an anal. method based on derivatization and normal-phase chromatog. In this way a sample of glycerol formal is calibrated for use as a std. in the direct detn. of the two components by polar-bonded-phase HPLC.