Detail of "54698-11-2"

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The metabolism of some 1-hydroxylated indoles in the rat

The metabolism of some 1-hydroxylated indoles in the rat. Acheson, R. M.; Nwankwo, J. O. (Dep. Biochem., Univ. Oxford, Oxford OX1 3QU, UK). Xenobiotica, 14(11), 877-83 (English) 1984. CODEN: XENOBH. ISSN: 0049-8254. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A no. of N-hydroxylated indole derivs. were fed to rats and the urinary metabolites were compared with those obtained on feeding the corresponding N-unsubstituted indoles. 1-Methoxyindole [54698-11-2] and 1-acetoxyindole [54698-12-3] were metabolized to compds. normally obsd. on feeding indole [120-72-9]. 1-Hydroxyindole-3-carboxylic acid [18377-48-5] and 1-methoxyindole-3-carboxylic acid [91913-76-7] were both partially excreted unchanged and reduced to indole-3-carboxylic acid [771-50-6], which was excreted along with its glucuronide. Indole-3-glyoxylic acid [1477-49-2] and its 1-methoxy deriv. [69111-70-2] were excreted almost entirely unchanged. 1-Hydroxyindole-3-glyoxlic acid [69111-87-1] was mostly excreted unchanged, but some redn. to indole-3-glyoxylic acid took place. The stability of these acids was assocd. with their low pKa values. The significance of the removal in vitro of groups attached through O to the 1 position of indoles is discussed in relation to the synthesis of new potential medicinal agents.

A palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate as a transfer agent

All Rights Reserved. A palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate as a transfer agent. Ishikura, Minoru; Takahashi, Norinobu; Yamada, Koji; Yanada, Reiko ( Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan). Tetrahedron, 62(50), 11580-11591 (English) 2006 Elsevier Ltd. CODEN: TETRAB. ISSN: 0040-4020.In this article, certain chemicals are used. Some of their cas registry numbers are 163977-05-7 and 54698-11-2 DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Investigation of the palladium-catalyzed tandem cyclization-cross-coupling reaction using indolylborate as a transfer agent has been carried out. E.g., reaction of indolylborate I, prepd. in situ from 1-methylindole and BEt3, with 2-IC6H4N(COPh)CH2CYCMe in presence of Pd(OAc)2 gave 78% (E)-indole isomer II. Furthermore, the cross-coupling reaction performed under carbon monoxide led to the generation of indolyl ketones. .