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547-64-8

Basic Information
CAS No.: 547-64-8
Name: Methyl lactate
Article Data: 161
Molecular Structure:
Molecular Structure of 547-64-8 (Methyl lactate)
Formula: C4H8O3
Molecular Weight: 104.106
Synonyms: DL-Methyllactate;Methyl 2-hydroxypropanoate;Methyl 2-hydroxypropionate;Methyllactate;Methyl a-hydroxypropionate;NSC 406248;
EINECS: 208-930-0
Density: 1.085 g/cm3
Melting Point: -66°C
Boiling Point: 145.3 °C at 760 mmHg
Flash Point: 47.1 °C
Solubility: miscible, hydrolyses with water
Appearance: clear colorless liquid
Hazard Symbols: IrritantXi
Risk Codes: 10-36/37
Safety: 24
Transport Information: UN 3272 3/PG 3
PSA: 46.53000
LogP: -0.45980
Synthetic route
600-22-6

pyruvic acid methyl ester

547-64-8

methyl lactate

Conditions
ConditionsYield
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;100%
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium hydrogencarbonate In methanol at 25℃; under 7500.75 Torr; for 12h; Glovebox; Autoclave; chemoselective reaction;98%
With hydrogen; Et4N91%
67-56-1

methanol

547-64-8

methyl lactate

Conditions
ConditionsYield
tetrabutoxytitanium at 170℃; for 4h; Product distribution / selectivity;99.8%
67-56-1

methanol

96-26-4

dihydroxyacetone

547-64-8

methyl lactate

Conditions
ConditionsYield
With tin containing MWW type β-zeolite In decane at 119.84℃; for 24h; Reagent/catalyst;99%
With Y-zeolite H-USY-6 In water at 115℃; for 24h; Inert atmosphere;96%
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Inert atmosphere; Autoclave; chemoselective reaction;95.5%
67-56-1

methanol

56-82-6

Glyceraldehyde

547-64-8

methyl lactate

Conditions
ConditionsYield
With tin containing MWW type β-zeolite In decane at 119.84℃; for 24h; Reagent/catalyst;99%
With Y-zeolite H-USY-6 In water at 115℃; for 48h; Inert atmosphere;98%
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Inert atmosphere; Autoclave; chemoselective reaction;91.7%
75-07-0

acetaldehyde

547-64-8

methyl lactate

Conditions
ConditionsYield
98.8%
67-56-1

methanol

849585-22-4

LACTIC ACID

547-64-8

methyl lactate

Conditions
ConditionsYield
With iron(III) sulfate; sulfuric acid for 3h; Heating;97%
With ethenetetracarbonitrile for 48h; Ambient temperature;88%
at 25 - 72℃; Product distribution / selectivity;87%
67-56-1

methanol

56-81-5

glycerol

547-64-8

methyl lactate

Conditions
ConditionsYield
With phosphotungstic acid at 130℃; for 4h; Reagent/catalyst; Autoclave; Inert atmosphere; Green chemistry;96%
With Na/MgO at 160℃; under 30402 Torr; for 5h; Reagent/catalyst; Inert atmosphere;80%
With magnesium oxide at 300℃; under 150015 Torr; for 1.5h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube;23.9 mol
With oxygen at 160℃; under 3750.38 Torr; Reagent/catalyst; Temperature; Autoclave;
With air; AuPd/carbon nanotubes + Sn-MCM-41-XS at 140℃; under 22502.3 Torr; for 4.5h; Catalytic behavior; Reagent/catalyst; Autoclave; Green chemistry;90 %Chromat.
67-56-1

methanol

138-22-7

n-butyl lactate

547-64-8

methyl lactate

Conditions
ConditionsYield
iodine for 15h; Heating;90%
67-56-1

methanol

96-26-4

dihydroxyacetone

A

547-64-8

methyl lactate

B

35830-93-4

2-hydroxy-3-methoxypropionaldehyde

Conditions
ConditionsYield
With calcined Sn-modified beta zeolite at 70℃; for 4h;A 86%
B n/a
67-56-1

methanol

78-97-7

2-hydroxy-propionitrile

547-64-8

methyl lactate

Conditions
ConditionsYield
With hydrogenchloride; water at -10 - -5℃; for 4h; Reflux;85.58%
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Chemistry

Synonyms: METHYL DL-LACTATE;METHYL (+/-) LACTATE;METHYL LACTATE;LACTIC ACID METHYL ESTER;DL-METHYL LACTATE;2-HYDROXYPROPANOIC ACID METHYL ESTER;1-hydroxyethanecarboxylicacid,methylester;2-hydroxy-propanoicacimethylester
EINECS: 208-930-0
METHYL LACTATE is the chemical compound with the formula C4H8O3.Its Molecular Weight is 104.1.
Boiling point:35 °C (6 mmHg) 
density:1.093 g/mL at 20 °C(lit.)
refractive index:n20/D 1.413
Flash point:49 °C 
storage temp.:Flammables area
Water Solubility:miscible, hydrolyses

Toxicity Data With Reference

1.   

ipr-rat LDLo:>2 g/kg

   JPPMAB    Journal of Pharmacy and Pharmacology. 11 (1959),150.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Slightly toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes:Xi
METHYL LACTATE 's Risk Statements:
10:Flammable 
36/37:Irritating to eyes and respiratory system 
METHYL LACTATE 's Safety Statements:
24:Avoid contact with skin 
RIDADR:UN 3272 3/PG 3
WGK Germany:1
RTECS:OD5670000
HazardClass:3.2
PackingGroup:III