Detail of "5470-96-2"

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CAS Number:
5470-96-2
Name:
2-Quinolinecarboxaldehyde
Molecular Structure:
Formula:
C₁₀H₇NO
Molecular Weight:
157.17
Synonyms:
Quinaldaldehyde(6CI,7CI,8CI);2-Formylquinoline;2-Quinolylaldehyde;2-Quinolylcarbaldehyde;NSC 27026;Quinoline-2-carbaldehyde;
EINECS:
226-804-3
Density:
1.223 g/cm³
Melting Point:
70-72 °C(lit.)
Boiling Point:
314.3 °C at 760 mmHg
Flash Point:
151.9 °C
Appearance:
white to light yellow crystal powder
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-37/39 Details

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Synthesis of 2-(2-quinolyl)chromone derivatives: Synthesis of 2-(2-quinolyl)chromone derivatives. Hsu, Kuang-Kan; Chang, Si-Fu (Sch. Pharm., Natl. 89-84-9 is the cas registry number. This chemical is also mentioned in this article. Taiwan Univ., Taipei, Taiwan). T'ai-wan K'o Hsueh, 31(3-4), 130-5 (English) 1977. CODEN: TKHSAU. ISSN: 0371-845X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 2-Quinolinecarboxaldehyde was condensed with 2'-hydroxyacetophenones to give the quinolylacrylophenones I (R = 5-Cl, 5-Br, 5-HO, 5-MeO, 5-CO2H, 5-Me, 4-HO, 4-MeO, 4-PhCH2O, 4-EtO2CCH2) which were oxidized with SeO2 to give the quinolychromones II (R = H, 6-Cl, 6-Br, 6-Me, 6-HO, 7-MeO) or with H2O2 to give the quinolylhydroxychromones III (R = H, 6-Cl, 6-Br, 6-Me, 6-MeO, 6-CO2H, 7-PhCH2O, 7-EtO2CCH2O). 2-Quinolinecarboxaldehyde was prepd. by treating PhNH2 with paraldehyde to give 2-methylquinoline which was oxidized with SeO2. .

Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells: All Rights Reserved.Several substances are used for example 5470-96-2 and 894695-24-0 which are their cas registry numbers. Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells. Adsule, Shreelekha; Barve, Vivek; Chen, Di; Ahmed, Fakhara; Dou, Q. Ping; Padhye, Subhash; Sarkar, Fazlul H. (Prevention Program and Department of Pathology, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI 48201, USA). Journal of Medicinal Chemistry, 49(24), 7242-7246 (English) 2006 American Chemical Society. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 78 (Inorganic Chemicals and Reactions) Section cross-reference(s): 1, 72 The authors report the synthesis of novel 1:1 Schiff base Cu complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. Copper quinoline thiosemicarbazone (2) (FPA-137) was the most potent and inhibited proteasome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 mM, resp.) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 mM), supporting the novelty of 2. .