Reference

Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities

Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities. Seidlova-Wuttke, D.; Hesse, O.; Jarry, H.; Rimoldi, G.; Thelen, P.; Christoffel, V.; Wuttke, W. (Department of Clinical and Experimental Endocrinology and Department of Urology, University of Goettingen, Goettingen D-37075, Germany). Phytomedicine, 11(5), 392-403 (English) 2004 Elsevier GmbH. CODEN: PYTOEY. ISSN: 0944-7113. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Belamcanda chinensis (BC) belongs to the family of iridaceae and the isoflavone tectorigenin has been isolated from the rhizome of this plant. Whether this isoflavone has estrogenic, possibly selective estrogen receptor modulator activities and if so, whether they are mediated via the estrogen receptor a or b is unknown at present. Therefore, we performed binding studies with recombinant human ERa and ERb to show that tectorigenin binds to both receptor subtypes. In ERa-expressing MCF7 and ERb-expressing MDA-MB231 reporter gene transfected cells tectorigenin causes transactivation. When given i.v. to ovariectomized (ovx) rats, it inhibits pulsatile pituitary LH secretion. In postmenopausal women estrogen-unopposed LH pulses correlate with hot flushes. Therefore, suppression of pulsatile LH secretion may be beneficial in women suffering from hot flushes. Upon chronic application to ovx rats a BC ext. contg. 5% Belamcanda at a daily dose of 33mg or 130mg of the ext. had no effect on uterine wt. or on estrogen-regulated uterine gene expression while estrogenic effects in the bone, on bone mineral d. of the metaphysis of the tibia could be established. Hence, tectorigenin may have antiosteoporotic effects also in postmenopausal women. Immunohistochem. staining of proliferating cell nuclear antigen-a proliferation marker-in the mammary gland did not indicate a mammotrophic effect of the tectorigenin-contg. BC ext. at both tested doses. In summary, tectorigenin or the B. chinensis ext. contg. tectorigenin had a strong hypothalamotropic and osteotropic effect but no effect in the uterus or the mammary gland. 548-77-6 and 50-28-2 are just another two chemicals used in this study. Therefore, tectorigenin may be in the future a clin. useful selective estrogen receptor modulator. .

Pharmaceutical composition for treatment of periodontal diseases and anti-inflammation

Pharmaceutical composition for treatment of periodontal diseases and anti-inflammation. Kim, Mun Mu; Seok, Jae Gyun; Kim, Sang Nyeon; Kim, Jeong Hun; Park, Sang Gi; Lee, Hak Mo (LG Chemical Co.In this study， 632-85-9 and 548-77-6 are also used., Ltd., S. Korea). Repub. Korean Kongkae Taeho Kongbo KR 2000041190 A 15 Jul 2000, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: A61K035-78. APPLICATION: KR 1998-56996 22 Dec 1998. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 A pharmaceutical compn. having excellent effect on periodontal diseases, rheumatoid arthritis, metastasis of cancer and inflammation is provided which inhibits the prodn. of collagenase, nitric oxide, superoxide, prostaglandin, interleukin-1b, tumor necrosis factor. A pharmaceutical compn. comprises the followings: one or more matrix metalloprotease inhibitor selected from the group of dried velamen, which is from leaves and roots of Ulmus macrocarpa, Ulmus pumila or Ulmus davidiana, and dried leaves of Camellia sinensis O. Ktze; one or more inhibitor of nitric oxide and superoxide selected from the group of quercetin, rutin, taxifolin, kaempferol, myricetin, curcumin, resveratrol, arecoline, apigenin, wogonin, luteolin and tectorigenin; one or more prostaglandin inhibitor selected from the group of dried velamen, which is from stem of Salix babylonica Linnaeus, Evodiae fructus and Clematidis radix. The content of matrix metalloprotease inhibitor, inhibitor of nitric oxide and superoxide and prostaglandin inhibitor is 0.0001-5% each based on total wt. .