Detail of "549-84-8"

Reference

Interaction between yohimbine alkaloids and amphetamine in mice

Interaction between yohimbine alkaloids and amphetamine in mice. Lambert, G. A.; Lang, W. J. (Pharmacol. Dep., Univ. Melbourne, Parkville, Aust.). Psychopharmacology (Berlin), 51(2), 209-12 (English) 1977. CODEN: PSCHDL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The toxicity (LD50) of the isomers yohimbine-HCl (I-HCl) [65-19-0] .beta.-yohimbine-HCl [549-84-8] and corynanthine [483-10-3] was detd. in mice. The LD50 of d-amphetamine sulfate [51-63-8] in the presence of a const. 483-10-3 and 51-63-8 which are cas registry numbers are also used here. dose of I and that of the isomer in the presence of a const. dose of amphetamine were detd. in aggregated mice. Isobolograms were constructed from these data and used to evaluate the interaction of the I alkaloids and amphetamine. .beta.-Yohimbine was approx. twice as toxic as I and corynanthine about 1/5 as toxic. There was a mutual potentiation between the toxicities of I and amphetamine. Potentiation of the toxicity of amphetamine occurred with .beta.-yohimbine but the effect was not as marked as with I. In contrast, corynanthine antagonized the toxicity of amphetamine. The interaction between I and amphetamine is unlikely to be due to noradrenergic mechanisms but could conceivably involve serotonergic or dopaminergic mechanisms. .

Separation and preparation of indole alkaloids in Lycorma delicatula White by HPLC

Separation and preparation of indole alkaloids in Lycorma delicatula White by HPLC. Xue, Gongda; Yuan, Sitong (Inst. Chinese Materia Medica, Chinese Academy Traditional Chinese Medicine, Beijing 100700, Peop. Rep. China). Zhongguo Zhongyao Zazhi, 21(9), 554-555 (Chinese) 1996 Zhongguo Yaoxuehui Zhongguo Zhongyi Yanjiuyuan Zhongya Yanjiuso. CODEN: ZZZAE3. ISSN: 1001-5302. DOCUMENT TYPE: Journal CA Section: 12 (Nonmammalian Biochemistry) Section cross-reference(s): 31 A HPLC method for sepg. and prepg. indole alkaloids was described. HPLC conditions for anal. were: BIO-RAD series 700 HPLC, model 700 data station, column of BIO-RAD Hi-pore RP381 and 250 mm ′ 10 mm, mobile phase of 80% methanol-H2O (gradient), flow rate of 1.5 mL min-1, and detection wavelength of 254 nm. 4 Compds. were sepd. On the basis of spectral (1HNMR, 13CNMR, H-H COSY, MS, DEPT) and chem.In this experiment, several chemicals are used like 483-04-5 and 549-84-8 evidence, 2 compds. were identified as b-yohimbine (yohimban-16-carboxylic acid, 17-hydroxy, Me ester, (3a, 16a, 17a)-) and ajmalicine (oxayohimban-16-carboxylic acid, 16,17-didehydro-19-Et, Me ester, (19a)-). .