Reference

Euglena, as a cellular model used in pharmacology for studying the effects of citrulline malate on lactate metabolization

Euglena, as a cellular model used in pharmacology for studying the effects of citrulline malate on lactate metabolization. Briand, Joel; Astoin, Jacques; Laval-Martin, Danielle; Calvayrac, Regis (Lab. Membr. Biol., Univ. Paris 7, Paris 75012, Fr.). Comp. Biochem. Physiol.Several reagents with their cas registry numbers 56-65-5 and 50-21-5 are used here., B: Comp. Biochem., 85B(3), 553-8 (English) 1986. CODEN: CBPBB8. ISSN: 0305-0491. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Euglena gracilis, Grown in darkness in a medium contg. 33 mM lactic acid [50-21-5] as the sole C source, was used to study the effect of citrulline malate [54940-97-5] on the lactate metab. and B1?3 glucan formation. The glucan formation pathway is similar to that in hepatic cells while transform blood lactate to glycogen. This system is used as a model to study the effect of drugs such as citrulline malate on blood lactate metab. during exercise. Addn. of 0.5 g/L of citrulline malate to the lactate culture medium accelerated lactate consumption and increased carboxylation and the ATP [56-65-5] pool, as compared to the control. .