Reference

Regulation of resistance to various toxicants by PCN (pregnenolone-16

Regulation of resistance to various toxicants by PCN (pregnenolone-16.alpha.-carbonitrile) and thyroxine. Tache, Y.; Tache, J.; Mecs, I.Chemicals with cas numbers 57-33-0 and 53-21-4 also play role.; Du Ruisseau, P.; Selye, H. (Inst. Med. Chir. Exp., Univ. Montreal, Montreal, Que., Can.). J. Med. (Westbury, N. Y.), 7(6), 471-9 (English) 1976. CODEN: JNMDBO. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 1 In rats, pregnenolone-16.alpha.-carbonitrile (I) [1434-54-4] (1 or 10 mg twice daily, orally) inhbited the toxicity of antazoline [91-75-8], carbamazepine [298-46-4], cocaine-HNCl [53-21-4], guanethidine [55-65-2], ibuprofen [15687-27-1], ketamine-HCl [1867-66-9], LSD [50-37-3], nembutal [57-33-0], and reserpine [50-55-5], whereas (except in the case of nembutal) thyroxine Na salt (I Na salt) [55-03-8] sensitized the animals to intoxication with these same compds. Even much lower doses of I or II exerted similar but weaker effects. I-induced resistance to the various substrates was generally not altered by concurrent administration of II but in a few cases its protective action was partially or totally inhibited, depending on the resp. dose levels of both compds. .

Thermoregulatory effects of peripheral catecholamines on the pigeon after treatment with thyroxine or thiouracil

Thermoregulatory effects of peripheral catecholamines on the pigeon after treatment with thyroxine or thiouracil. Saarela, S.; Hissa, R. (Dep.In this study， 141-90-2 and 51-40-1 are also used. Zool., Univ. Oulu, Oulu, Finland). Comp. Biochem. Physiol. C, 56(1C), 25-30 (English) 1977. CODEN: CBPCBB. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 12 After treatment with thyroxine (I) [55-03-8] (75 .mu.g/kg), thiouracil (II) [141-90-2] (3 mg/kg), or 0.85% NaCl every 2 days for 3 weeks either at 22 or 2.degree., pigeons were peripherally injected with noradrenaline (III) [51-40-1] (1-3 mg/kg) at both 6 and 32.degree.; after I treatment, III caused more marked hypo- or hyperthermia at 6 or 32.degree. resp. than after treatment with II. Repeated I or II injections increased the plasma glucose level at 22.degree. but not at 2.degree.; there were no changes in lipolytic activity after 3 weeks of treatment. All examd. tissues of I-treated pigeons consumed more O in vitro than did those of II-treated pigeons and the I-treated tissues were more sensitive to added III (10-4M). Thus I potentiates the hypo- or hyperthermic effects of III below or above the thermoneutral zone and this effect is counteracted by II. .