Detail of "55-91-4"

CAS Number:
55-91-4
Name:
Phosphorofluoridicacid, bis(1-methylethyl) ester
Molecular Structure:
Formula:
C6H14 F O3 P
Molecular Weight:
184.17
Synonyms:
Phosphorofluoridicacid, diisopropyl ester (8CI); DFF; DFP; DFP (pesticide); Difluorophate;Diflupyl; Diisopropoxyphosphoryl fluoride; Diisopropyl fluorophosphate;Diisopropyl phosphofluoridate; Diisopropyl phosphorofluoridate; Dyflos;Floropryl; Fluorodiisopropyl phosphate; Fluostigmine; Isoflurophate; Isopropylfluophosphate ((C3H7O)2FPO); Isopropyl phosphorofluoridate ((C3H7O)2FPO);Neoglaucit; O,O-Diisopropyl phosphorofluoridate
Density:
1.079g/cm³
Melting Point:
−82 °C(lit.)
Boiling Point:
62 °C9 mm Hg(lit.)
Flash Point:
64.5°C
Hazard Symbols:
Cholinesterase inhibitor.
Risk Codes:
R26/27/28;
Safety:
A poison by ingestion, inhalation, skin contact, intraperitoneal, subcutaneous, intramuscular, ocular, and intravenous routes. Moderately toxic by parenteral route. Human systemic effects by inhalation: miosis (pupillary constriction) and headache. Experimental reproductive effects. Used as a basis for “nerve gases.” An insecticide. Ingestion can cause damage to eyes, nausea, vomiting, diarrhea, and central nervous system disturbances. An FDA proprietary drug. Used as a miotic agent. When heated to decomposition it emits toxic fumes of F⁻ and PO_x. See also PARATHION. Details

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Effects of diisopropylfluorophosphate (DFP) on renal function in the rat: Effects of diisopropylfluorophosphate (DFP) on renal function in the rat. Berndt, W. O.; Baggett, J.; Hoskins, B.; Lim, D. K.; Ho, I. K. (Coll. Med., Univ. Nebraska, Omaha, NE, USA). Toxicology, 31(3-4), 223-35 (English) 1984. CODEN: TXCYAC. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) An irreversible cholinesterase [9001-08-5] inhibitor, diisopropylfluorophospate (DFP) [55-91-4](1-4 mg/kg, s.c.) was tested on renal function in rats. A single dose of DFP (2, 3 or 4 mg/kg) caused an increased flow of urine of low osmolality over the 6 h after the administration of the drug with essentially a return to control status by 24 h after either of the lower doses. Twenty-four hours after 4 mg/kg, urine vol. was less and urine osmolality greater than control. Renal and brain cholinesterases remained depressed 24 h after DFP. In acute expts. on anesthetized animals, inulin clearance was increased by the lower doses and decreased by the highest dose of DFP. Renal blood flow measured with an electromagnetic flow meter showed a similar dose-response relationship. However, urine flow increased at all doses. The increased urine flow assocd. with decreased inulin clearance (4 mg/kg) and renal blood flow (3 or 4 mg/kg) suggest a direct effect of DFP on renal tubular function. These effects do not appear to be related to inhibition of cholinesterase.

Separation of molecular forms of rat brain soluble acetylcholinesterase (AChE) by polyacrylamide gel electrophoresis for the study of the modifications during intoxication by DFP: Separation of molecular forms of rat brain soluble acetylcholinesterase (AChE) by polyacrylamide gel electrophoresis for the study of the modifications during intoxication by DFP. Bisso, Guillermo Mario; Marcacci, Gianni; Michalek, Hanna (Lab. Pharmacol., Ist. Super. Sanita, Rome 00161, Italy). Electrophor. '83 [Eighty-Three], Adv. Methods, Biochem. Clin. Appl., Proc. Int. Conf., 4th, Meeting Date 1983, 423-6. Edited by: Hirai, Hidematsu. de Gruyter: Berlin, Fed. Rep. Ger. (English) 1984. CODEN: 51YDAV. DOCUMENT TYPE: Conference CA Section: 4 (Toxicology) Section cross-reference(s): 7 Three main mol. forms of acetylcholinesterase (AChE) [9000-81-1] (mol. wts. 115,000, 340,000, and 740,000) were sepd. from rat brain and isolated by polyacrylamide gel electrophoresis. Rats treated with DFP [55-91-4] showed a transient increase in the medium mol. wt. form of AChE during recovery from max. inhibition of AChE by DFP.